Fishbane S, Frei GL, Maesaka J
Reduction in recombinant human erythropoietin doses by the use
of chronic intravenous iron supplementation
Am J Kidney Dis
(Jul) 26:41-46 1995
Fifty two patients taking EPO and oral iron, without laboratory
evidence of iron deficiency (mean serum ferritin of about 185 ng/ml
and mean transferrin saturation of 22%, baseline Hct 32%) were
randomized to receive either oral or IV iron. Oral iron was the
sulfate in 21 patients and polysaccharide in 11. The IV iron dose
(Infed) was 100 mg twice weekly IV push over 2 min. IV iron was
given to the oral iron group if TSAT < 12.5% or if ferritin < 50.
After 4 months, in the routine IV iron group, Hct was higher (34.4
vs. 31.8), and the EPO dose lower (4,000 U/tx vs. 7,600 U/tx), and the
ferritin was higher (750 vs.
160). TSAT was 75% vs. 20%. Four months after stopping routine
Infed, ferritin had decreased to 180 and TSAT to 20%. A test dose
of 25 mg Infed was used prior to each IV iron dose, and no
anaphylactic reactions to Infed were observed. The results suggest
that some form of semi-routine IV iron supplementation is useful in
dialysis patients, although it appears that the perhaps the dose
used may have been too high, and that the dose needs to be tailored
to the individual patient.
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
CRF by problem area :