Kailasam MT, Parmer RJ, Cervenka JH, WU A, Ziegler MG,
Kennedy BP, Adegbile IA, O'Connor DT
Divergent effects of dihydropyridines and phenylalkalamine calcium
channel antagonist classes on autonomic function in human
(Jul) 26:143-149 1995
This study compared the acute and chronic effects of two different
classes of calcium antagonists, i.e. felodipine (dihydropyridine
class) and verapamil (phenylalkylamine class), on sympathetic
outflow measures in 15 patients with essential hypertension.
Patients taking dihydropyridine drugs demonstrated decreases in
blood pressure associated with increased sympathetic activity as
assessed by reflex tachycardia and elevation of plasma
norepinephrine activity. Conversely, patients receiving verapamil
evidenced suppressed sympathetic activity.
may be one explanation why therapy of hypertension with
dihydropyridine calcium antagonists does not reduce mortality in
spite of good apparent blood pressure control (see NHLBI news alert).
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
H: Drug therapy :
Calcium channel blockers