Arnold A, Brown MF, Urena P, et al.
Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia

J Clin Invest (Jul) 95:2047-2053 1995

Hemodialysis patients often have low serum HDL cholesterol and high triglycerides. The latter is believed to be a consequence of reduced lipoprotein lipase (LPL) activity. A group of 85 subjects with a wide range of renal function was carefully selected to eliminate other conditions, such as proteinuria and inflammation, to specifically study lipoprotein concentrations and LPL activity. Compared with previous reports, this investigation revealed only a modest increase in triglycerides in patients with advancing renal impairment. Increased triglyceride concentration did not correlate with decreased LPL activity in moderate renal insufficiency. In advanced renal failure reduced LPL activity may have contributed to hypertriglyceridemia. A primary alteration in lipoprotein structure in renal failure may be the cause of reduced lipoprotein clearance leading to hypertriglyceridemia. (Paller)

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CRF by problem area : Bone disease/aluminum