Arnold A, Brown MF, Urena P, et al.
Monoclonality of parathyroid tumors in chronic renal failure
and in primary parathyroid hyperplasia
J Clin Invest
(Jul) 95:2047-2053 1995
Hemodialysis patients often have low serum HDL cholesterol and high
triglycerides. The latter is believed to be a consequence of reduced
lipase (LPL) activity. A group of 85 subjects with a wide range of renal
function was carefully selected to eliminate other conditions, such as
proteinuria and inflammation, to specifically study lipoprotein
and LPL activity. Compared with previous reports, this investigation revealed
only a modest increase in triglycerides in patients with advancing renal
impairment. Increased triglyceride concentration did not correlate with
decreased LPL activity in moderate renal insufficiency. In advanced renal
failure reduced LPL activity may have contributed to hypertriglyceridemia. A
primary alteration in lipoprotein structure in renal failure may be the cause
reduced lipoprotein clearance leading to hypertriglyceridemia.
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