Massy ZA, Ma JQ, Louis TA, Kasiske BL
Lipid-lowering therapy in patients with renal disease
(Jul) 48:188-198 1995
This is a meta-analysis to compare various lipid-lowering interventions in
patients with renal disease. Controlled and uncontrolled studies from
MEDLINE were included if they addressed therapies including diet, exercise,
drugs (including ACE inhibitors and NSAIDs in nephrotic syndrome and LMW
heparin in HD pts). Weighted multiple linear regression analysis indicated
that HMG-CoA reductase inhibitors decreased LDL by -51 to -84 mg/dl and
fibric acid derivatives lowered triglycerides by -69 to -132 mg/dl. Other
interventions had inconsistent effects.
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