Welch M, Newstead CG, Smyth V, Dodd PD, Walker MG
Evaluation of dopexamine hydrochloride as a renoprotective agent during aortic surgery

Ann Vasc Surg (Sep) 9:488-492 1995

ATN is common after aortic surgery. The effect of a new synthetic intravenous catecholamine dopexamine was studied in a randomized controlled study of 15 patients given 2 ug/kg/min of the drug vs. 17 patients. given saline. Renal failure (>30% increase in serum creatinine or >30% decrease in creatinine clearance) occurred in 8 (47%) of saline-treated vs. 2 (13%) of dopexamine-treated patients. No patient required dialysis. It is concluded that dopexamine protects vs. renal impairment in patients. undergoing aortic surgery.

Comment: Criteria for determination of renal impairment are flawed since a 30% increase in serum creatinine is not equivalent to a 30% decline in clearance; moreover, the number of patients studied was small and the clinical relevance of the findings is not clear. (Leehey)

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ARF etiology : Post surgical