Al-Momen AK, Shaheen FAM, El-Aqeil NE, Sheikh IA, Braimo WA
Bezafibrate in the management of vascular access and dialyzer thrombosis

Dial Transplant (Sep) 24:509-511 1995

Bezafibrate, a clofibrate analogue used in the treatment of hyperlipidemia, also has effects on hemostasis, including a lowering of plasma fibrinogen levels, enhancement of fibrinolysis, elevation of low ATIII levels, and depression of platelet aggregability. Al-Momen and colleagues gave 200 mg daily to 9 patients with frequent dialyzer clotting episodes and to 8 HD patients without dialyzer clotting problems for four weeks. Fibrinogen levels were decreased in both groups, from 4.7 to 2.6 g/L in the clottingİprone group and from 4.0 to 2.5 g/L in controls. During the 4-week follow-up period, there were no episodes of dialyzer clotting. Also, 3 of the 9 patients had an access thrombosis during the 8 weeks preceding bezafibrate therapy, and it is claimed that access clotting incidence was reduced as well. However, any conclusions with regard to access thrombosis are obviously overstated.

Comment: The findings are interesting with regard to dialyzer clotting. This study was done using new dialyzers. It would be interesting to see if the reuse number is increased in patients taking bezafibrate. (Daugirdas)

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Basic hemodialysis : Vascular Access: graft/fistula
CRF by problem area : Anemia/Erythropoietin/Iron