Pereira BJG, Snodgrass B, King AJ, Barger G, Chopra S,
Cytokine production during in vitro hemodialysis with new and
formaldehyde- or renalin-reprocessed cellulose dialyzers
J Am Soc Nephrol
(Oct) 6:1304-1308 1995
Reprocessing of dialyzers has been shown to attenuate complement activation
by cellulose membranes; however, there is concern that reprocessing may be
associated with increased cytokine production which could be lead to
increased morbidity and mortality. To test this hypothesis, the production
of interleukin (IL)-1a by peripheral blood mononuclear cells (PBMC) during in
vitro dialysis with new or reprocessed dialyzers was compared. Whole blood
from healthy volunteers was circulated for 3h in the blood compartment; the
dialysate compartment was sealed. Total IL synthesis by unstimulated and
endotoxin-stimulated PBMC was measured by RIA. IL production was increased
slightly but not significantly by new dialyzers, formaldehyde-reprocessed
dialyzers and renalin-reprocessed dialyzers; endotoxin-stimulated IL
production was significantly increased with new dialyzers and
formaldehyde-reprocessed dialyzers but not by renalin-reprocessed dialyzers.
These data do not support the hypothesis that reprocessing of dialyzers
increases IL production.
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Basic hemodialysis :
Reuse, theory and practice