Dudley CRK, Keavney B, Stratton IM, Turner RC, Ratcliffe PJ
U.K. Prospective Diabetes Study XV: Relationship of renin-
angiotensin gene polymorphism with microalbuminuria in
(Dec) 48:1907-1911 1995
A case-control study was performed to determine whether molelcular variants
of genes of the renin-angiotensin system were associated with albuminuria in
NIDDM. 180 patients with persistent microalbuminuria and control diabetics
with similar glycated hemoglobin and lipid levels without microalbuminuria
were compared. Some controls were also matched for blood pressure. No
significant differences in ACE genotype or angiotensinogen genotype between
cases and controls were noted. However, microalbuminuric patients with ACE
DD genotype had significantly greater albumin excretion than those with a
non-DD genotype. The mechanism by which the DD genotype might be related to
the severity of albuminuria is unclear.
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