Barba G, Cappuccio FP, Russo L, Stinga F, Iacone R,
Renal function and blood pressure response to dietary salt
restriction in normotensive men
(May) 27:1160-1164 1996
Previous studies in black hypertensives and salt-sensitive Dahl
rats have suggested that hyperfiltration and increased glomerular pressure
occurs in these conditions. This study was designed to try to delineate the
mechanism of salt sensitivity (i.e., hypertensive response to salt loading)
in healthy men.
Forty seven healthy male volunteers were studied on a habitual high sodium
diet (urinary sodium 184 mmol/24h) and a sodium restricted diet (urinary
sodium 69 mmol/24h). Measurements included glomerular filtration rate (GFR)
and lithium clearance (CLi).
Salt sensitivity correlated with GFR and absolute proximal sodium
reabsorption [APR = (GFR - CLi) x serum Na]. Subjects with salt sensitivity
had increased GFR and APR during the habitual diet.
Comment: Increased proximal sodium reabsorption leading to increased
BP, and GFR (to overcome the impaired sodium excretion) may occur in
(David J. Leehey, M.D., Loyola University at Chicago)
For original abstract from the AHA,