Stegeman CA, Tervaert JWC, de Jong PE, Kallenberg CGM for the
Dutch Co-trimoxazole Study Group
Trimethoprim-sulfamethoxazole (co-trimoxazole) for the
prevention of relapses in Wegener's Granulomatosis
N Engl J Med
(Jul) 335:16-20 1996
When DeRemee first reported marked improvement in a patient with Wegener's
granulomatosis when treated with trimethoprim-sulfamethoxazole, I am sure
many people chuckled. The paper by Stegeman suggests that there is something
here that can no longer be dismissed. Whether the drug is acting in an
antimicrobial or non-specific capacity, of course, cannot be determined.
The abstract of this paper is available from the National Library of
Medicine's PubMed site:
click here .
For accompanying editorial by DeRemee: