Fliser D, Franek E, Fode P, Stefanski A, Schmitt CP, Lyons M,
Subacute infusion of physiologic doses of parathyroid hormone
raises blood pressure in humans
Nephrol Dial Transplant
(May) 12:933-938 1997
Hypertension is common in hyperparathyroidism.
Iseki, Massry, and Campese
noted that PTH had a permissive role in the hypertension
associated with hypercalcemia.
Peter Pang and colleagues
have suggested the existence in SHR rats of a parathyroid
factor, distinct from PTH, although it's specific structure remains to be
How hyperparathyroidism might cause hypertension is otherwise unknown, as PTH
hypotensive effect when injected into animals. In this paper, Fliser et al
"physiologic" doses of 1,34-PTH into normal non-uremic humans, and found
serum calcium, platelet calcium, and MAP. The increases in MAP correlated
increases in platelet calcium levels. The increase in MAP were tiny (84 to
Hg), but they did correlate with changes in platelet calcium levels. Whether
has a role in the hypertension of uremia remains unknown.
The abstract of this paper is available from Oxford Press