HDCN Article Review/Hyperlink

Fliser D, Franek E, Fode P, Stefanski A, Schmitt CP, Lyons M, Ritz E

Subacute infusion of physiologic doses of parathyroid hormone raises blood pressure in humans

Nephrol Dial Transplant (May) 12:933-938 1997

Hypertension is common in hyperparathyroidism. Iseki, Massry, and Campese noted that PTH had a permissive role in the hypertension associated with hypercalcemia. Peter Pang and colleagues have suggested the existence in SHR rats of a parathyroid hypertensive factor, distinct from PTH, although it's specific structure remains to be identified. How hyperparathyroidism might cause hypertension is otherwise unknown, as PTH has a hypotensive effect when injected into animals. In this paper, Fliser et al inject "physiologic" doses of 1,34-PTH into normal non-uremic humans, and found increases in serum calcium, platelet calcium, and MAP. The increases in MAP correlated with increases in platelet calcium levels. The increase in MAP were tiny (84 to 88 mm Hg), but they did correlate with changes in platelet calcium levels. Whether PTH has a role in the hypertension of uremia remains unknown.

The abstract of this paper is available from Oxford Press at this site.