HDCN Article Review/Hyperlink

Wardlaw JM, Warlow CP, Counsell C

Systematic review of evidence on thrombolytic therapy for acute ischaemic stroke

Lancet (Aug) 350:607-614 1997

Because of a single trial   showing that early administration of tissue plasminogen activator may be beneficial in acute stroke the US FDA approved t-PA for this indication. However, the present review takes a more sober view, and points out that the benefits of t-PA are not clearcut, that the risk of hemorrhage is indeed increased, that the risk of bleeding may be very high with concomitant aspirin ingestion (and many such patients will be taking aspirin), and that most typical patients will not be eligible for such therapy.

The abstract of this paper is available from the National Library of Medicine's PubMed site: click here .