HDCN Article Review/Hyperlink

Rosendaal FR, Siscovick DS, Schwartz SM, Psaty BM, Raghunathan TE, Vos HL

A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women

Blood (Sep) 90:1747-1750 1997

Rosendaal and colleagues have published 3 papers in the last 6 months identifying three heretofore unknown risk factors for myocardial infarction in young women. In this paper, they find that a factor II (prothrombin) variant (20210 G to A) was associated with an odds ratio of 4.0. In a previous paper in April in Blood, they found a slightly weaker association (odds ratio = 2.4) with the Factor V Leiden mutation. Finally, in the July issue of Circulation , they found an odds ratio of about 2.0 associated with plasma total homocysteine levels greater than 15.6 µM. So risk of MI becomes a more interesting story than just smoking, hypertension, and cholesterol. (Daugirdas)