HDCN Article Review/Hyperlink

Shihab FS, Bennett WM, Tanner AM, Andoh TF

Angiotensin II blockade decreases TGF-beta1 and matrix proteins in cyclosporine nephropathy

Kidney Int (Sep) 52:660-673 1997

This paper paper suggests that ACE inhibitors (or losartan) mitigate the adverse renal effects of cyclosporine (less tubulointerstitial nephropathy and less arteriolar disease) in a rat model. The paper is interesting because there was a paper in NDT recently, by Hannedouche et al   suggesting that ACE inhibitors improve renal function in juvenile diabetics given cyclosporine.   There was another paper by Elliott et al.   in heart transplant patients on cyclosporine also suggesting a beneficial effect. Of course ACE-I have been used to Tx post- transplant erythrocytosis. Some papers suggest an adverse effect of ACE-Is post transplant, and others suggest a neutral effect; e.g., Garcia et al.  vs. Mourad et al.   

The abstract of this paper is available from the National Library of Medicine's PubMed site: click here .