Shihab FS, Bennett WM, Tanner AM, Andoh TF
Angiotensin II blockade decreases TGF-beta1 and matrix proteins
in cyclosporine nephropathy
(Sep) 52:660-673 1997
This paper paper suggests that ACE inhibitors (or
losartan) mitigate the adverse renal effects of cyclosporine (less
tubulointerstitial nephropathy and less arteriolar disease) in a rat model.
The paper is interesting because there was a paper in NDT recently,
by Hannedouche et al
suggesting that ACE
inhibitors improve renal function in juvenile diabetics given cyclosporine.
There was another paper
by Elliott et al.
in heart transplant patients on cyclosporine also
suggesting a beneficial effect. Of course ACE-I have been used to Tx post-
erythrocytosis. Some papers suggest an adverse effect of ACE-Is post
others suggest a neutral effect; e.g.,
Garcia et al.
Mourad et al.
The abstract of this paper is available from the National Library of
click here .