HDCN Article Review/Hyperlink

Brodsky RA, Petri M, Smith BD, Seifter EJ, Spivak JL, et al

Immunoablative high dose cyclophosphamide without stem cell rescue for refractory, severe autoimmune disease

Ann Intern Med (Dec) 129:1031-1035 1998

Eight patients with severe, refractory, autoimmune disease, among them two with lupus, received high dose cyclophosphamide (50 mg/kd/day) for 4 days, without stem cell rescue, followed by granulocyte-colony stimulating factor. One woman with membranous lupus had "continuous complete remission 12 months after treatment", with resolution of anti-DNA antibodies and a 24-hr urinary protein excretion of only 86 mg. Taking only 1 mg/day of prednisone. Another case of lupus with antiphospholipid syndrome is described as being in partial remission, with reduction of prednisone dose to 5 mg qod. In total, five of the 8 patients treated for a variety of disease are reported to be in complete remission. (John T. Daugirdas, M.D., University of Illinois at Chicago)