Agnello V, Adel G, Knight GB, Civati G, Colombo V,
Confalonieri R, Grillo C, Montoli A
Cryoglobulinemic glomerulonephritis: in situ hybridization for
HCV in renal tissue
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A23 1996
In order to find a pathogenetic link between renal lesions and HCV
infection, Agnello et al. tried to detect by in situ hybridization,
the putative virion and the replicative form of HCV in renal tissue
of 12 patients affected by HCV correlated cryoglobulinemic
glomerulonephritis.
The non replicating form of HCV was only
found in a third of the paraffin-embedded renal biopsies studied,
while viral replication could not be detected. Moreover, the non
replicating form was only localized at the tubular level. This last
finding seems to argue against a direct pathogenetic role of HCV in
glomerular damage.
Comment: RNA is a unstable and
easily degradable molecule particularly in paraffin embedded tissue.
Thus, further studies using frozen tissue are warranted to completely
exclude a pathogenetic involvement of HCV in renal damage. (Loreto
Gesualdo, M.D., University of Bari, Italy)
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33rd Congress of the Eur Dial Transplant Assoc
Proteinuria/Hematuria :
Cryoglobylonemia not due to hepatitis
Proteinuria/Hematuria :
Hepatitis-associated nephropathy