Benedetto FA, Tripepi G, Cambareri F, Panuccio V, Enia V,
Mallamaci F, Zoccali C, Tassone F
Hypertension and nocturnal hypoxemia in chronic renal failure
12th Annual ASH Meeting
Am J Hypertens
(Apr) 10:192A 1997
The relatively high prevalence of sleep apnea in ESRD patients
is increasingly recognized. Transient hypoxia elicits
pathophysiologic responses which include hypertension. A significant
group of ESRD patients are "non-dippers", i.e. they do not show a
normal fall in BP during sleep. This study aims at correlating these
two phenomena.
Thirty-two ESRD patients (HD and PD percentages were not given) underwent
24 hour
ambulatory BP monitoring with nocturnal pulse oximetry recording. 13
(41%) did not desaturate; 19 desaturated at least once, and 12 (38%)
desaturated 10 or more times. Daytime SBP in these patients with frequent
desaturation were no different from SBP in those without
desaturation, but nocturnal SBP rose in the former and fell in the
latter group.
Comment: It thus appears that aside from the expected acute rises in
SBP during desaturation, these patients. are "non-dippers". The entire
topic of sleep disorders and nocturnal BP control in ESRD is of
increasing interest, particularly in view of the potential impact on
mortality. The abstract lacks some of the demographic comparisons of
the groups, especially weight and underlying lung disease.
(James A. Sondheimer MD, Wayne State University, Detroit, MI)
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12th Annual ASH Meeting
H: Pathophysiology :
Sleep, sleep apnea