Gustafsson F, Torp-Pedersen C, Kober L, Hildebrandt for the
TRACE Study Group
A history of arterial hypertension increases benefit of ACE
inhibition after acute myocardial infarction
12th Annual ASH Meeting
Am J Hypertens
(Apr) 10:79A 1997
Infarct expansion may pose a greater risk for hypertensives, and this may
be attenuated with ACE inhibitors. Therefore, this group evaluates the
effect of ACE inhibitors in a selected group of hypertensive patients with
LV systolic dysfunction and an ejection fraction below 35 %. The study is
a retrospective analysis of the "Trace" study, from Denmark.
Analysis of data from 1749 patients with AMI and decreased LV function
showed a marked reduction in the relative risk of death (RR) from any
cause in the hypertensive group (0.59, p < 0008). On the other hand, the
reduction was not significant for normotensives.
Comment: This paper convincingly shows that ACE inhibitors result in
a
significant decrease in the RR for death after an AMI in hypertensives
with a reduced LV systolic function.
(Armando Lindner, M.D., University of Washington, Seattle)
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12th Annual ASH Meeting
H: Drug therapy :
ACE inhibitors
H: Pathophysiology :
Heart in hypertension