Wofford MR, Miller ME, Cameron ME, Willoughby DL, Adair CM,
Jones DW
Effects of weight loss intervention in HOT weight loss substudy
participants
12th Annual ASH Meeting
Am J Hypertens
(Apr) 10:84A 1997
The authors performed a substudy of 114 Hypertension Optimal
Treatment (HOT) Study participants. The purpose of the study was
to determine whether intensive dietary counseling was an
effective method for maintaining weight reduction. Subjects with
a body mass index of >27 were randomized into a weight loss or a
control group. Participants in the weight loss group received
dietary counseling by a registered dietician and participated in
group counseling throughout a 24-month period. Control group
participants were advised to lose weight but no special
counseling was provided.
The intervention group lost 4.4 ± 0.34
kg during the first 6 mo but this was not maintained with more
prolonged follow-up. The authors conclude that there is a
rebound effect associated with dietary counseling; i.e., short-
term success does not translate into long-term success.
Comment: Weight loss is known to decrease blood pressure and is
recommended by the JNC. However, achieving a stable reduction in
weight is very problematic and requires a highly motivated
patient. Diminished compliance with weight reduction was also
noted in the TOMHS study
(Neaton JD et al. JAMA 1993; 270:713).
(David J. Leehey, M.D., Loyola University at Chicago)
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12th Annual ASH Meeting
H: Special problems :
Obesity, Insulin Resistance