Harden PN, Geddes C, Rowe PA, Boulton-Jones M, et al.
ACE gene polymorphism and progression of renal disease
Am Soc Nephrol
J Am Soc Nephrol (abstract) (Nov) 6:390 1995

In this paper 347 patients were studied with chronic renal disease. 41% had IgA nephropathy, 33% adult polycystic kidney disease, and 26% chronic pyelonephritis. The rate of progression was quantified serial serum creatinine measurements. In patients with the DD ACE genotype, the rate of progression (-2.6 ml/min/yr) was greated than in patients with the ID or II genotypes. Apparently the only subgroup that this was significant for was that with IgA nephropathy.

Comment: This abstract is in agreement with the data of Hamaguchi et al (98/389). (Daugirdas)

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Am Soc Nephrol
CRF by problem area : Progression