Stokes MB, Chawla H, Gertner R, Brody RI, Goldfarb D, Gallo G
Glomerular disease in HIV-infected patients with hepatitis C virus
Am Soc Nephr
J Am Soc Nephrol (abstract) (Nov) 6:433 1995

A group of 14 HIV positive patients were studied 12 of whom were hepatitis C antibody positive, one was negative and one not tested. They all presented with a clinical syndrome of high BP, edema, hematuria and low C3 (9 of 13 tested); cryoglobulins were present in 5 of 8. Renal biopsy showed membranoproliferative GN in 6, mesangial proliferative GN in 6, membranous nephropathy in 1 and glomerular sclerosis with mesangial immune deposits in 1. HCV RNA was detected in 7 of 11 patients; 4 of 5 cryoglobulinemic patients had HCV RNA in renal tissue. The authors conclude that HIV patients coinfected with HCV may exhibit a distinct clinicopathological condition from HIV associated nephropathy. (Pastan)

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Am Soc Nephr
Proteinuria/Hematuria : Hepatitis-associated nephropathy
Proteinuria/Hematuria : HIV-associated nephropathy