Tarnow L, Rossing P, Jacobsen P, Nielsen FS, Cambien F, Lecerf L, Poirier O, Parving H-H
Progression of diabetic nephropathy and the insertion/deletion polymorphismof the ACE gene
Am Soc Nephrol
J Am Soc Nephrol (abstract) (Nov) 6:457 1995

In this paper by Tarnow et al. 40 diabetic patients with insulin- dependent diabetes mellitus were studied. They all were normotensive. Rate of progression over a 3 year period was measured and correlated with presence of the DD ACE genotype. 19 of the patients had the DD genotype. In this group there was no difference in the rate of progression from that in the group with other ACE genotypes, although there was a trend in the DD group for a faster rate of decline in ClCr (3 ml/min/yr vs. 1.1 ml/min/yr in non-DD patients).

Comment: Although this study was negative, the trends were such that they suggest that DD ACE genotype diabetics may indeed suffer from accelerated decline in renal function, and larger trials may reveal a positive result. (Daugirdas)

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Am Soc Nephrol
Proteinuria/Hematuria : Diabetes
CRF by problem area : Progression