12th Annual ASH Meeting --Apr: 1997

Selected Abstracts




Hypertension


Heart in hypertension

h Reversible pulmonary edema due to bilateral renal artery stenosis
h Determinants of left ventricular structure after kidney transplantation
h Time course of complete regression of left ventricular hypertrophy during long-term anti-hypertensive therapy with ACE-inhibitors
h Dobutamine stress echocardiography for detection of coronary artery disease in hypertensive patients
h Prognostic value of serial changes in left ventricular mass in essential hypertension

Genetics

h Relation between deletion polymorphism of the ACE gene and left ventricular hypertrophy in hypertensive treated men

Kidney in hypertension

h Which urinary proteins are decreased after ACE inhibition?

Sleep, sleep apnea

h Hypertension and nocturnal hypoxemia in chronic renal failure

Sympathetic nervous system

h Effect of 4 weeks of amlodipine therapy on muscle sympathetic nerve activity

Ambulatory monitoring

h Values of 1,2,3 hour segments or ambulatory blood pressure pattern in essential hypertension
h Nondipper hypertensive patients and ambulatory blood pressure reproducibility
h The temporal stability (correlation) of mean awake and sleep ambulatory blood pressure

Arm cuff

h Blood pressure determination using the random zero and standard mercury sphygmomanometers

Tests for LVH

h Are the sensitivity and specificity of ECG criteria for LVH so bad?

White coat hypertension

h 15-year development of stable hypertension in borderline hypertension with abnormal pressor response to mental stress
h Target organ damage in subjects with white-coat and sustained hypertension: an insight from the HARVEST study

Role of exercise

h Walking exercise reduces blood pressure in mild essential hypertension

Outcomes

h Treatment with calcium channel blockers does not increase the risk of fatal and non-fatal cancer in an elderly European population: STEPHY II results

Endocrine hypertension

h Normokalemic primary aldosteronism
h Hemodynamics effects of correction of hyperparathyroidism by vitamin D in hemodialysis patients

Obesity, Insulin Resistance

h Changes in sympathetic activity and insulin sensitivity during body weight reduction in obese subjects
h Effects of weight loss intervention in HOT weight loss substudy participants

Renovascular hypertension

h Detection of severe bilateral renovascular disease by ACE-induced renal dysfunction

Smoking, ethanol, substance abuse

h Chronic alcohol intake rises blood pressure in normotensive and essential hypertensive patients: assessment by 24-h ABPM
h The effect of smoking on left ventricular structure and function in hypertensive patients
h Effect of alcohol on ambulatory blood pressure and target organs in subjects with mild hypertension

Women

h Safety aspects of calcium channel blockers in patients with hypertension associated with pregnancy: A retrospective study
h Influence of oral contraceptive pill on ambulatory blood pressure in normotensive women
h Effect of menopause on clinic and ambulatory blood pressure
h Gender differences in insulin sensitivity and sympathetic responsiveness in young hypertensives
h Antihypertensive medications and cardiovascular disease in a large cohort of U.S. women
h Estrogen replacement therapy improves renal vascular response to L- arginine in menopausal women with essential hypertension
h Effect of menopause on day-night blood pressure changes and left ventricular function in hypertension
h Ambulatory blood pressures, not office blood pressure, decline during estrogen replacement therapy in postmenopausal women

ACE inhibitors

h Early treatment with lisinopril after acute myocardial infarction: Are risks greter than benefits in hypertensives? Results of the GISSI-3 database
h A history of arterial hypertension increases benefit of ACE inhibition after acute myocardial infarction
h Life span extension of genetically hypertensive rats after long-term ACE-inhibition correlates to enhanced NO-availability
h The angiotensin type II receptor may partly be involved in antihypertensive effects exerted by type I receptor antagonists in hypertensive rat
h Greater hypotension during renin than ACE-inhibition associated with decresed plasma AI but not AII

Acute hypertensive crisis

h Emergency department management of hypertensive emergencies: A comparison of fenoldopam mesylate (Corlopam) versus sodium nitroprusside

Calcium channel blockers

h Calcium antagonists and sympathetic activity
h A double-blind trial comparing mibefradil and amlodipine: long-acting calcium antagonists with similar efficacy but different tolerability profiles

Compliance

h Appropriate antihypertensive therapy in current practice. Results of a feasibility study
h Compliance as a function of initial choice of antihypertensive drug

Cost-effectiveness

h Outcome of a mandatory formulary conversion of nifedipine XL to felodipine in a Veterans Affairs Medical Center

Dietary/electrolyte therapy

h Magnesium supplementation increases blood pressure in spontaneously hypertensive rats
h Dietary potassium is more determining of salt-sensitivity in normotensive blacks than whites
h Effects of a low-potassium diet on blood pressure and salt excretion in black and white subjects
h The influence of potassium intake on dipper vs. non-dipper blood pressure status in adolescents


Dialysis, Chronic Renal Failure


Cardiovascular/Hypertension

d Plasma homocysteine, endothelin, and left ventricular hypertrophy in patients with end-stage renal disease
d Myths and reality of hypertension in peritoneal dialysis: results of a multicenter study


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