Am Soc Nephrol --Nov: 1995

Selected Abstracts




Dialysis, Chronic Renal Failure


Vascular Access: graft/fistula

d The relation of brachial artery flow to access flow
d The relation of recirculation to access flow
d The relation of intra-access pressure to intra-access flow
d Do patients with angiographically proven access stenosis have low access blood flow?
d Access blood flow measurements in the low flow range by an ultrasonic device are accurate
d A new, Fick-principle based method for measuring blood flow in hemodialysis grafts validated by magnetic resonance angiography
d Access recirculation by ultrasonic dilution compared to a 20 sec slow flow method
d Simplified accurate measurement of access recirculation with an in- line hematocrit device
d Extracorporeal venous drip chamber pressure measurement screening does not predict impending hemodialysis access graft failure
d Increasing AV fistulas for hemodialysis access
d Measurement of access flow by thermodilution: in vitro experiments
d Mutation at Arg506 of coagulation factor V and access thrombosis in hemodialysis patients
d The efficacy and complications of aspirin versus heparin in post-operative prophylaxis against thrombosis in newly placed hemodialysis access

Vascular Access: venous

d Blood recirculation in central temporary catheters for acute hemodialysis

Dialyzers

d In vitro clearance of advanced glycosylated end-products by conventional and high flux hemodialysis membranes

Complications (acute)

d The protective effect of cool dialysate is dependent on patients' predialysis body temperature
d Relationship between blood volume and inferior cava diameter during and after short and long hemodialysis
d The intradialytic effects of oral L-carnitine: results of a double blind placebo controlled trial

Dialysis machines

d Safety of hemodialysis machines: Surveillance of the venous blood return

Home hemodialysis

d Long-term combination home automated peritoneal dialysis and in-center hemodiafiltration for progressive neuropathy in end stage renal disease

Adequacy, prescription, urea kinetics

d Screening for extreme postdialysis urea rebound using the Smye method
d Cardiac index affects urea rebound to the extent predicted by the regional blood flow model
d Effect of intradialytic exercise on urea kinetics and rebound
d Intradialytic exercise increases effective dialysis efficiency and reduces rebound

Physiology

d Fluctuations of urea generation rate following protein intake in hemodialysis patients measured using [13-C]-urea

Reuse, theory and practice

d Heat sterilization of dialyzers: maximized reuse with 1.5% citric acid and 95 degrees C
d Effect of Renalin reprocessing on small and large solute clearances by hemodialyzers

Cardiovascular/Hypertension

d Hypoalbuminemia: a major risk factor for cardiac disease in ESRD
d Hypertension, cardiomyopathy, cardiac morbidity and mortality in ESRD
d Increased homocysteine values, a risk factor for premature coronary artery disease, prevail in patients on hemodialysis
d The effect of fluid loading on blood pressure in hemodialysis patients
d Arteriosclerosis, not atherosclerosis is common in end-stage renal disease: related factors
d Sudden cardiac death and autonomic nerve dysfunction in hemodialysis patients
d Effect of blood pressure on survival in a prevalent cohort of hemodialysis patients

GI/Liver, Hepatitis

d Long-term virological response after alpha-interferon therapy in HCV- positive hemodialysis patients
d Trends in the incidence of hepatitis C infection in hemodialysis units
d Dialysis room and reuse strategies that affect the incidence of hepatitis C infection in HD units
d Beta-2-microglobulin amyloidosis involving the GI tract in hemodialysis

Neurological

d Severe neuropathy predicts mortality in non-diabetic dialysis patients

Anemia/Erythropoietin/Iron

d Role of endogenous erythropoietin in the hematopoietic response to iron administration in hemodialysis patients
d Interferon-gamma mediates resistance to erythropoietin in uremic patients with inflammatory disease
d Response to iron dextran therapy is not precluded by high serum ferritin
d Endogenous erythropoietin levels are elevated in patients on continuous ambulatory peritoneal dialysis
d Factors predictive of suboptimal iron stores in hemodialysis patients with normal iron indices
d Amelioration of left ventricular hypertrophy in long-term hemodialysis patients
d Effect of chronic human erythropoietin therapy on immune response in chronic hemodialysis patients
d Cell therapy for erythropoeitin-deficient anemias
d Underdialysis impairs response to erythropoietin in hemodialysis patients
d Low iron absorption in erythropoietin-treated haemodialysis patients
d Can the erythropoietin dose be lowered safely? A case-control study of subcutaneous administration
d The safety and efficacy of intraperitoneal erythropoietin in children on CCPD
d Correction of anemia does not improve growth or endocrine function in children with ESRD: A report from the U.S. multicenter pediatric recombinant erythropoietin study
d Comparison of 3 iron dextran infusion methods to correct anemia in erythropoietin treated hemodialysis patients

Bone disease/aluminum

d High phosphorus directly simulates PTH secretion by human parathyroid tissue
d Bone mineral loss in chronic renal failure: a difference between young and old CRF patients
d Low-dose DFO treatment (5 mg/kg) in acutely aluminum intoxicated dialysis patients using two drug administration schedules
d Expression in pathalogic parathyroid tissue of calcium receptor and vitamin D receptor gene message
d Expression of Bcl-2 oncoprotein in parathyroid tissue of patients with primary and secondary hyperparathyroidism
d Calcium-regulated parathyroid hormone release before and after successful long-term calcitriol therapy in secondary hyperparathyroidism
d Non-suppressible parathyroid hormone secretion is related to parathyroid gland size in uremic secondary hyperparathyroidism
d Serum phosphorus strongly correlates with PTH in mild chronic renal failure
d Suppression of PTH by 22-oxacalcitriol in hemodialysis patients with secondary hyperparathyroidism
d Marked expression of c-fos/jun proteins in hyperplastic parathyroid glands
d Mild osteodystrophy: Is it really a mild disease?
d Nasal calcitonin reduces bone loss in renal transplant recipients
d Effect of aging on renal responsiveness to parathyroid hormone in healthy men
d In vivo effect of intravenous 1,25-dihydroxyvitamin D3 on interleukin-2 production in hemodialysis patients
d Serum parathyroid hormone levels as a peredictor of the skeletal resopnse to intermittent calcitriol therapy
d Phosphate restriction prevents parathyroid cell growth in uremic rats and high phosphate directly stimulated PTH secretion in tissue culture
d Secondary hyperparathyroidism complicated by parathyromatosis
d Monoclonal proliferation of nodues in parathyroid hyperplasia due to chronic renal failure
d Vitamin D receptor gene polymorphism and severity of secondary hyperparathyroidism

CRF and diabetes

d Depletion of advanced glycated end-products (AGEs) in uremic serum and dialysis fluid by an AGE-binding lysozyme-matrix

Infections (other than hepatitis, peritonitis)

d Hepatitis C viral infection and HIV co-infection in hemodialyzed patients
d Access-related infection in HIV-seropositive dialysis patients: comparison of hemodialysis to peritoneal dialysis
d Preoperative vancomycin prophylaxis decreases the incidence of hemodialysis vascular access infections

Nutrition

d Increased dialysis prescription improved nutrition
d Can we reconcile metabolic acidosis and nutritional status in hemodialysis patients?
d Elevated serum C-reactive protein is a strong predictor of increased mortality and low serum albumin in hemodialysis patients
d Lean body mass estimation by different techniques in healthy controls and peritoneal dialysis patients
d Dialysis adequacy and nutrition in CAPD: a prospective study
d Use of a 1.1% amino acid dialysis solution to treat malnutrition in peritoneal dialysis patients
d Linkage between adequacy of dialysis and nutrition in CAPD patients
d Predictors of malnutrition in maintenance hemodialysis patients
d Effect of insulin-like growth factor 1 on nitrogen balance in malnourished CAPD patients

Outcomes (Morbidity, Mortality)

d Residual renal function in hemodialysis and continuous ambulatory peritoneal dialysis patients
d High cytokine levels may mediate the high mortality of hemodialysis patients with low albumin and cholesterol
d Patient survival on CAPD: comparison between Canada and the United States
d Cardiac disease in endstage renal disease: A comparison of hemodialysis and peritoneal dialysis
d Comparison of mortality risk by Kt/V single pool vs. double pool analysis in diabetic and non-diabetic dialysis patients
d Effect of serial APACHE and organ failure scores on prediction of mortality in acute renal failure
d Association of serum bicarbonate to survival in hemodialysis: a non-linear relationship
d Early death in dialysis patients: risk factors and impact on incidence and mortality rates
d Predictors of short-term mortality in diabetic hemodialysis patients

Complications of PD

d Increased risk of adverse outcome in immunosuppressed patients undergoing CAPD

PD solutions, equipment

d Effect of amino acid based dialysate on peritoneal blood flow and permeability during CAPD
d CAPD using a self-made, ultrafiltration-sterilized, bicarbonate-based solution

PET testing

d Correlation between peritoneal transport type and peritoneal protein losses

Physiology

d Pressure causes fluid loss from the peritoneal cavity to the body
d Effect of acutely raising the serum albumin on peritoneal transport and ultrafiltration in CAPD patients

Peritonitis and exit-site infection

d Bacteria grow better if pH of CAPD solutions is elevated from 5.0 to 6.4, offsetting improvement in neutrophil phagocytosis
d Peritonitis influences mortality in PD patients

Chronic PD regimens, adequacy, modeling

d The creatinine excretion ratio is an unreliable indicator of non- compliance in PD patients
d Urea and weekly creatinine clearances measured by direct quantification: Comparison in APD, CAPD, and conventional HD
d Formula to calculate nitrogen losses in patients treated with chronic peritoneal dialysis
d Comparison of 2 year survival on hemodialysis and peritoneal dialysis with dose of dialysis matched using the peak concentration hypothesis
d Association between adequacy and nutrition in CAPD -- genuine or artifact?

Etiology

d Attribution of hypertension as the underlying cause of ESRD: does race matter?
d Low birth weight a risk factor for development of diabetic nephropathy?

Progression

d ACE gene polymorphism and progression of renal disease
d Urinary transforming growth factor beta-1 and progression of glomerular diseases
d Magnitude of end-stage renal disease in IDDM: 35 year follow-up study
d Effect of dietary protein restriction on the progression of non- diabetic renal disease: meta-analysis

Continous therapies

d Limiting continuous venovenous hemofiltration in acute renal failure
d Treatment of volume overload in patients with acute renal failure by intermittent hemodialysis
d Microspheres for specific adsorption as supplement for hemodialysis in acute renal failure
d Cytokine removal and cardiovascular hemodynamics in patiens with ARF and treatment with CVVH
d Incidence of hypothermia during continuous renal replacement therapy
d Bicarbonate dialysate for continuous renal replacement therapy
d Continuous veno-venous hemodialysis in septic patients


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