Note: Feedback portion of this quiz will work only with Internet Explorer, and not with Firefox.
Oh
Ethylene Glycol Poisoning
(Man S. Oh, MD. ASN Renal Week 2005).
How is ethylene glycol metabolized, and which metabolites are toxic? What form of calcium oxalate crystals are produced, and is the dihydrate envelope-shaped calcium oxalate crystal
frequently seen? Is glycolic acid really the toxic substance in ethylene glycol poisoning, or is it the aldehydes, or the glyoxylic acid? Is metabolism to oxalate or to glycine more important? How
does metabolism of ethylene glycol affect acid load? Osmlolal gap? Why might the urinary osmolal gap be of interest? How do we use ethanol and fomepizole in the management of ethylene glycol
poisoning? When and for how long do we dialyze?
(more...)
Why and when do marathon runners become hyponatremic? How much should they drink? What should then drink? Are NSAIDs a risk factor? What is the nephrogenic syndrome of inappropriate diuresis, and what is its molecular and genetic basis? How does sildenafil act on aquaporins to increase water transport in the kidney? How does "ecstasy" cause hyponatremia? How can we use CRRT to safely treat extreme hypernatremia? How to thiazolidinediones cause edema? What is pyroglutamic acidosis? How can medication containing propylene glycol cause acidosis? How does acidosis affect protein synthesis in the kidney? What is hensin and how can it explain cyclosporine caused metabolic acidosis? How to topamax, linezolid, and propofol cause acidosis? How does bicarbonate ingestion boost athletic performance? (more...)
Dr. Chris O'Callaghan,
M.D.
BA, BM, BCh, MA, MRCP (UK), DPhil
Medical Research Council Clinician Scientist
Institute of Molecular Medicine and, Nuffield Department of Clinical Medicine
University of Oxford, John Radcliffe Hospital, Oxford, UK