key Try Dr. Aronoff's BASIC ESRD PHARMACOKINETICS . This quiz deals with issues of dialyzability of drugs, how to give drugs to ESRD patients that are removed by dialysis, with examples of severe side effects from two drugs that can manifest in ESRD patients.
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Aronoff

Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer?
How does epoetin alfa work? What is CERA and how is it different? What are the half-lives of various ESAs and how may this impact therapy and cost? What is Hematide and how does it work? What are prolyl hydroxylase inhibitors and how do they affect anemia? What are initial results with FG-2216? How can ESA dosing be individualized using a neural net approach? (RPA 2006 Satellite Symposium) (more...)

Updated: September 03, 2010 (Sep03)
Sep03 Cranberry juics blocks ability of Staph aureus bacteria to form biofilm in the urinary bladder.
Sep03 Fish oils inactivate inflammatory effects of macrophages present around fat cells
Sep03 Novel antimalarial drug candidate shows promise.
Sep03 First clinical trials completed on potent new drug against hepatitis C.
Aug31 Could a vaccine against Staph aureus toxin alpha hemolysin (Hla) help in exit-site infection?
Aug31 Large study debunks notion that statins may be associated with cancer.
Aug29 Molecule found that deactivates selective components of the complement system.
Aug26 Genetic variants in protein kinase C affect CKD progression in type 2 diabetics of Chinese descent.
Aug26 Novartis options siRNA drug from Quark Pharma to reduce AKI and delayed allograft function.
Aug26 Back to the future: Renin profiling claimed to be useful in predicting response to RAAS inhibitors or beta-blockers.
Aug26 Naringenin from grapefruits shows promise as a treament for type 2 diabetes
Aug21 KDIGO initiative for improved drug dosing in patients with kidney disease
Aug20 Two FDA approved drugs cause HIV to mutate itself to death in mice.
Aug19 Vitamin D may improve allergic aspergillosis related diseases.
Aug17 FDA approves longer use of (200 days) of valganciclovir for CMV prophylaxis post transplant.
Industry Advances Emphasis
archive
"State-of-the-Art" Pharmacogenomics: Coming of Clinical Age? (S. Ginsburg) ASN Renal Week 2008
Biostatistics Workshop #2: Everything You Always Wanted to Know About Biostatistics, But Were Afraid to Ask (E. McCulloch) ASN Renal Week 2008
Genetic Epidemiology: A New Frontier (W. Bowden) ASN Renal Week 2008
Pharmacokinetics and the Aging Kidney (M. Bennett) ASN Renal Week 2008
Putting It All Together: Journal Club #2) (L. Johansen) ASN Renal Week 2008
Drug Dosing in AKI (A. Mueller) ASN Renal Week 2008
Polymorphisms in Drug Metabolism (Anglicheau) ASN Renal Week 2008
HD Patient Education on the Run (Dickenson) ADC 2008
Medications Prescribed for Chronic Dialysis Patients (Busch) ADC 2008
Renin Redux: Benefits of Blocking This System (A. Sica) ASN Renal Week 2007
Regulation Gene Expression in Diabetic Nephropathy by Epigenetic Modifications (El-Osta) ASN Renal Week 2007
Renal Failure with CsA/FK use in Non-Renal Transplant or ACE System (E. Thummel) ASN Renal Week 2007
Making Measurements of the Urine Proteome (Sharma) ASN Renal Week 2007
Monitoring Inflammation and Fibrosis/ Drug Management (N. Rush) ASN Renal Week 2007
Multidrug Approach to Target Non-Immunologic Factors (D. Scandling) ASN Renal Week 2007
Introduction to Pharmacogenomics (T. Turner) ASN Renal Week 2007
Epigenetic Regulation of Renal Development (R. Dressler) ASN Renal Week 2007
Epidemiology: Risky Business (Go) ASN Renal Week 2007
The Other Side of the RAAS Family: Renin Receptors, ACE 2, Ang III in the Kidney (R. Weir) ASN Renal Week 2007
Drug Dosing in AKI (A. Mueller) ASN Renal Week 2007
A Practical Approach to Pharmacokinetics in CKD Patients (A. Mueller) RRI 2007
Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer? (Aronoff) RPA Satellite Symposium 2006
Contrast Induced Nephropathy (CIN): Clinical Significance and Prevention (Palevsky, Tumlin) ASN Renal Week 2005 (audiofiles)
The Pathway to Approval of Novel Agents for Renal Diseases (Greene, Throckmorton, Lewis) ASN Renal Week 2005 (audiofiles)
Literature Review: Non-Potassium Fluid-Electrolyte and Acid-Base Disorders (Palmer) ASN Renal Week 2005
Specific Nephrotoxins (Molitoris, Berns, Palevsky, Shihab, Launay-Vacher, Isnard-Bagnis) ASN Renal Week 2005 (audiofiles)
General Aspects of Nephrotoxicity and Analgesics (Perazella, Markowitz, Clark, DeBroe, Elseviers, Henrich) ASN Renal Week 2005 (audiofiles)
Prescribing for Patients with CKD Including Dialysis (Swan, Bennett, DeBroe, D'Haese) ASN Renal Week 2005 (audiofiles)
Metals, the Environment, and Miscellaneous Toxins (Batuman, Nortier, Ritz, DeBroe, Lewis, Wolfe) ASN Renal Week 2005 (audiofiles)
New Phosphate Binders (Bargman) ADC 2005 (audiofiles)
Statins as Anti-Inflammatory Drugs (Wheeler) RRI 2005 (audiofiles)
Herbs and Heavy Metals: A Recipe for Kidney Failure (Kupin) ASN Board Review 2004

Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure (Siedlecki) Kidney Int (Apr 2009)
Balkan Nephropathy: Evolution of Our Knowledge (Bamias and Boletis) Am J Kidney Dis (Sep 2008)
Pharmacogenetics of immunosuppressants: progress, pitfalls and promises (Cattaneo D et al) Am J Transplant - Jul - 08
Efficacy and safety of fondaparinux and enoxaparin for acute coronary syndromes in CKD Am J Kidney Dis (May 2008)
Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis Hypertens (2008)
The Janus faces of allopurinol -- allopurinol hypersensitivity syndrome Am J Med (Mar 2008)
Beta-blockade in chronic dialysis patients Semin Dial (Feb 2008)
Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: Update regarding thiazolidinediones: a consensus statement from the ADA/EASD Diabet Care (Jan 2008)
Long term pharmacotherapy for obesity and overweight: updated meta-analysis (Rucker et al) Brit Med J (Dec 2007)
Drug dosing considerations in alternative hemodialysis (Decker et al) Adv Chronic Kidney Dis (Jul 2007)
Gadolinium use in patients with kidney disease: A cause for concern Semin Dial 05-07
Aldosterone and Cardiovascular Disease. Smoke and Fire (Calhoun). Circulation 12-06
(2006 Pharma )Year in Review (Michele B. Kaufman, PharmD, RPh) Dial-Transplant 12-06
Lessons for Medicare Part D in the hemodialysis community (Nayeem, Chertow) BMC Nephrology 07-06
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Dr. George Aronoff, M.D.
Professor of Medicine and Pharmacology, University of Louisville School of Medicine, Louisville, KY.