key Try Dr. Aronoff's BASIC ESRD PHARMACOKINETICS . This quiz deals with issues of dialyzability of drugs, how to give drugs to ESRD patients that are removed by dialysis, with examples of severe side effects from two drugs that can manifest in ESRD patients.
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Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer?

How does epoetin alfa work? What is CERA and how is it different? What are the half-lives of various ESAs and how may this impact therapy and cost? What is Hematide and how does it work? What are prolyl hydroxylase inhibitors and how do they affect anemia? What are initial results with FG-2216? How can ESA dosing be individualized using a neural net approach? (RPA 2006 Satellite Symposium) (more...)

Updated: October 05, 2016 (Oct05)
Oct05 FDA warns about hepatitis B reactivation with direct acting hepatitis C antivirals.
Jul28 Good Staph. in the nose makes novel peptide antibiotic that kills bad Staph.
May29 Three days of fasting every 10 days improve autoimmune diseases (in mice).
May29 Nicotinamide riboside protects mice from effects of diabetes.
May24 CRIC study shows a high urinary sodium excretion in CKD linked to higher CV risk.
May20 SPRINT shows lower than 120 BP systolic target in elderly results in improved outcomes
Apr27 Tetraspanin-7 as an antibody target for type 1 diabete
Apr13 New bacteria called Elizabethkingia affecting Midwest patients.
Mar30 AC6 gene therapy improves cardiac function in patients with heart failure.
Mar09 Desensitization procedure allows kidney transplants from any (living) donor.
Mar09 Is the FDA allowing promotion of off-label uses of drugs as free speech?
Feb29 Phage Therapy 2016 World Congress meets this June in Paris.
Feb29 When will be see phage therapy for exit site and access infections?
Feb27 Treatment of BP below 140 systolic in persons with diabetes may be counterproductive.
Feb20 New blood-based tuberculosis test shows promising results.
Industry Advances Emphasis
"State-of-the-Art" Pharmacogenomics: Coming of Clinical Age? (S. Ginsburg) ASN Renal Week 2008
Biostatistics Workshop #2: Everything You Always Wanted to Know About Biostatistics, But Were Afraid to Ask (E. McCulloch) ASN Renal Week 2008
Genetic Epidemiology: A New Frontier (W. Bowden) ASN Renal Week 2008
Pharmacokinetics and the Aging Kidney (M. Bennett) ASN Renal Week 2008
Putting It All Together: Journal Club #2) (L. Johansen) ASN Renal Week 2008
Drug Dosing in AKI (A. Mueller) ASN Renal Week 2008
Polymorphisms in Drug Metabolism (Anglicheau) ASN Renal Week 2008
HD Patient Education on the Run (Dickenson) ADC 2008
Medications Prescribed for Chronic Dialysis Patients (Busch) ADC 2008
Renin Redux: Benefits of Blocking This System (A. Sica) ASN Renal Week 2007
Regulation Gene Expression in Diabetic Nephropathy by Epigenetic Modifications (El-Osta) ASN Renal Week 2007
Renal Failure with CsA/FK use in Non-Renal Transplant or ACE System (E. Thummel) ASN Renal Week 2007
Making Measurements of the Urine Proteome (Sharma) ASN Renal Week 2007
Monitoring Inflammation and Fibrosis/ Drug Management (N. Rush) ASN Renal Week 2007
Multidrug Approach to Target Non-Immunologic Factors (D. Scandling) ASN Renal Week 2007
Introduction to Pharmacogenomics (T. Turner) ASN Renal Week 2007
Epigenetic Regulation of Renal Development (R. Dressler) ASN Renal Week 2007
Epidemiology: Risky Business (Go) ASN Renal Week 2007
The Other Side of the RAAS Family: Renin Receptors, ACE 2, Ang III in the Kidney (R. Weir) ASN Renal Week 2007
Drug Dosing in AKI (A. Mueller) ASN Renal Week 2007
A Practical Approach to Pharmacokinetics in CKD Patients (A. Mueller) RRI 2007
Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer? (Aronoff) RPA Satellite Symposium 2006
Contrast Induced Nephropathy (CIN): Clinical Significance and Prevention (Palevsky, Tumlin) ASN Renal Week 2005 (audiofiles)
The Pathway to Approval of Novel Agents for Renal Diseases (Greene, Throckmorton, Lewis) ASN Renal Week 2005 (audiofiles)
Literature Review: Non-Potassium Fluid-Electrolyte and Acid-Base Disorders (Palmer) ASN Renal Week 2005
Specific Nephrotoxins (Molitoris, Berns, Palevsky, Shihab, Launay-Vacher, Isnard-Bagnis) ASN Renal Week 2005 (audiofiles)
General Aspects of Nephrotoxicity and Analgesics (Perazella, Markowitz, Clark, DeBroe, Elseviers, Henrich) ASN Renal Week 2005 (audiofiles)
Prescribing for Patients with CKD Including Dialysis (Swan, Bennett, DeBroe, D'Haese) ASN Renal Week 2005 (audiofiles)
Metals, the Environment, and Miscellaneous Toxins (Batuman, Nortier, Ritz, DeBroe, Lewis, Wolfe) ASN Renal Week 2005 (audiofiles)
New Phosphate Binders (Bargman) ADC 2005 (audiofiles)
Statins as Anti-Inflammatory Drugs (Wheeler) RRI 2005 (audiofiles)
Herbs and Heavy Metals: A Recipe for Kidney Failure (Kupin) ASN Board Review 2004

Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure (Siedlecki) Kidney Int (Apr 2009)
Balkan Nephropathy: Evolution of Our Knowledge (Bamias and Boletis) Am J Kidney Dis (Sep 2008)
Pharmacogenetics of immunosuppressants: progress, pitfalls and promises (Cattaneo D et al) Am J Transplant - Jul - 08
Efficacy and safety of fondaparinux and enoxaparin for acute coronary syndromes in CKD Am J Kidney Dis (May 2008)
Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis Hypertens (2008)
The Janus faces of allopurinol -- allopurinol hypersensitivity syndrome Am J Med (Mar 2008)
Beta-blockade in chronic dialysis patients Semin Dial (Feb 2008)
Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: Update regarding thiazolidinediones: a consensus statement from the ADA/EASD Diabet Care (Jan 2008)
Long term pharmacotherapy for obesity and overweight: updated meta-analysis (Rucker et al) Brit Med J (Dec 2007)
Drug dosing considerations in alternative hemodialysis (Decker et al) Adv Chronic Kidney Dis (Jul 2007)
Gadolinium use in patients with kidney disease: A cause for concern Semin Dial 05-07
Aldosterone and Cardiovascular Disease. Smoke and Fire (Calhoun). Circulation 12-06
(2006 Pharma )Year in Review (Michele B. Kaufman, PharmD, RPh) Dial-Transplant 12-06
Lessons for Medicare Part D in the hemodialysis community (Nayeem, Chertow) BMC Nephrology 07-06
Tools, Calculators
Drug Dosing in Renal Failure
Topic Pages
Interstitial Nephritis
Adverse drug effects
Australian Prescriber
Drug Facts and Comparisons
Renal Pharmacist Network
U.S. Pharmacopoeia

Dr. George Aronoff, M.D.
Professor of Medicine and Pharmacology, University of Louisville School of Medicine, Louisville, KY.