key Try Dr. Aronoff's BASIC ESRD PHARMACOKINETICS . This quiz deals with issues of dialyzability of drugs, how to give drugs to ESRD patients that are removed by dialysis, with examples of severe side effects from two drugs that can manifest in ESRD patients.
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Aronoff

Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer?
How does epoetin alfa work? What is CERA and how is it different? What are the half-lives of various ESAs and how may this impact therapy and cost? What is Hematide and how does it work? What are prolyl hydroxylase inhibitors and how do they affect anemia? What are initial results with FG-2216? How can ESA dosing be individualized using a neural net approach? (RPA 2006 Satellite Symposium) (more...)

Updated: September 05, 2008 (S05)
S05 Bisphenol (present in polycarbonate plastics) linked to metabolic syndrome.
S02 In vitro studies suggest role for antihistamine clemizole in treating hepatitis C
S02 AJKD: Temporary iron depletion and relative thrombocytosis may underline increased mortality with high doses of EPO.
A29 Singh and Furberg editorialize against use of thiazolidinediones due to CV risk and lack of CV benefit.
A26 Allopurinol lowers blood pressure in hypertensive adolescents
A26 Leptin injections keep rats with type 1 diabetes alive without insulin.
A26 Twenty percent of Ayurvedic medicines found to be contaminated with lead, arsenic, or mercury.
A22 Some evidence that Vytorin is, or maybe is not, associated with an increased cancer risk; FDA gets involved.
A22 New antimicrobial approach tames, rather than kills, pathogenic bacteria, lowering risk of emerging resistant strains.
A21 AMAG receives fast track designation from FDA for ferumoxytol as an MRI contrast agent.
A20 Individual genome analysis shows that drug sensitivity may be poorly predicted by skin color (presumed race)
A19 Effect of grapefruit juice on drug absorption and metabolism: new complexities
A18 Researchers create milligram quantities of completely synthetic heparin
A14 SpyCEP identified as key element to infectivity of group A strep associated with necrotizing fasciitis.
A07 Bile acids play a role in glucose metabolism and insulin signaling.
Industry Advances Emphasis
archive
Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer? (Aronoff) RPA Satellite Symposium 2006
Literature Review: Non-Potassium Fluid-Electrolyte and Acid-Base Disorders (Palmer) ASN Renal Week 2005
The Pathway to Approval of Novel Agents for Renal Diseases (Greene, Throckmorton, Lewis) ASN Renal Week 2005 (audiofiles)
Contrast Induced Nephropathy (CIN): Clinical Significance and Prevention (Palevsky, Tumlin) ASN Renal Week 2005 (audiofiles)
Metals, the Environment, and Miscellaneous Toxins (Batuman, Nortier, Ritz, DeBroe, Lewis, Wolfe) ASN Renal Week 2005 (audiofiles)
Prescribing for Patients with CKD Including Dialysis (Swan, Bennett, DeBroe, D'Haese) ASN Renal Week 2005 (audiofiles)
General Aspects of Nephrotoxicity and Analgesics (Perazella, Markowitz, Clark, DeBroe, Elseviers, Henrich) ASN Renal Week 2005 (audiofiles)
Specific Nephrotoxins (Molitoris, Berns, Palevsky, Shihab, Launay-Vacher, Isnard-Bagnis) ASN Renal Week 2005 (audiofiles)
Statins as Anti-Inflammatory Drugs (Wheeler) RRI 2005 (audiofiles)
New Phosphate Binders (Bargman) ADC 2005 (audiofiles)
Herbs and Heavy Metals: A Recipe for Kidney Failure (Kupin) ASN Board Review 2004

Balkan Nephropathy: Evolution of Our Knowledge (Bamias and Boletis) Am J Kidney Dis (Sep 2008)
Pharmacogenetics of immunosuppressants: progress, pitfalls and promises (Cattaneo D et al) Am J Transplant - Jul - 08
Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis Hypertens (2008)
Efficacy and safety of fondaparinux and enoxaparin for acute coronary syndromes in CKD Am J Kidney Dis (May 2008)
The Janus faces of allopurinol -- allopurinol hypersensitivity syndrome Am J Med (Mar 2008)
Beta-blockade in chronic dialysis patients Semin Dial (Feb 2008)
Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: Update regarding thiazolidinediones: a consensus statement from the ADA/EASD Diabet Care (Jan 2008)
Long term pharmacotherapy for obesity and overweight: updated meta-analysis (Rucker et al) Brit Med J (Dec 2007)
Drug dosing considerations in alternative hemodialysis (Decker et al) Adv Chronic Kidney Dis (Jul 2007)
Gadolinium use in patients with kidney disease: A cause for concern Semin Dial 05-07
(2006 Pharma )Year in Review (Michele B. Kaufman, PharmD, RPh) Dial-Transplant 12-06
Aldosterone and Cardiovascular Disease. Smoke and Fire (Calhoun). Circulation 12-06
Lessons for Medicare Part D in the hemodialysis community (Nayeem, Chertow) BMC Nephrology 07-06
ESRD PHARMACOKINETICS
Drug Dosing in Renal Failure
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HDCN Topic Pages
Interstitial Nephritis
Adverse drug effects
OTHER LINKS
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Dr. George Aronoff, M.D.
Professor of Medicine and Pharmacology, University of Louisville School of Medicine, Louisville, KY.