Palevsky

Acute Renal Replacement Therapy

Paul M. Palevsky, MD
(ASN Board Review Course, August, 2008.)
Palevsky: Is it better to initiate dialysis earlier or later in the course of acute kidney injury? What did the early observational trials show, and were they confirmed by randomized trials? Is CRRT better than IHD? To what extent to the studies agree or disagree? If IHD, is 6/week better than 3/week? Why was the ATN study negative? How can it be reconciled with the study by Schiffl et al? In CRRT does the volume of replacement fluid used affect survival? How can we achieve maximum hemodynamic stability when dialyzing patients with AKI? What are the benefits and drawbacks of using citrate for anticoagulation? (more...)

Murray
Molitoris

Acute Kidney Injury. Congestive Heart Failure: A Nephrologist's Disease? (Murray) and AKI Therapeutics: From Bench to Commercialisation (Molitoris)

Patrick T. Murray, MD, FASN and Bruce A. Molitoris, MD
(ASN Renal Week Clinical Nephrology Conference, November, 2007.)
Murray: What's the role of the nephrologist in caring for patients with congestive heart failure? What should the optimal interaction be between nephrologists and cardiologists? What is cardiorenal syndrome? How does pharmacotherapy of congestive heart failure impact the kidney? What is the role of ultrafitration therapy?
Molitoris: What is the role of the academic medical center in commercializing new discoveries? In particular, what was the pathway for commercialization of a new method of supravital imaging of renal function through in vivo fluorescence microscopy that was developed at Indiana University? (more...)


key This quiz by Dr. Michael Kraus and Dr. Ed Sha deals with ANTICOAGULATION IN CRRT . It discusses the various anticoagulation methods available, their relative utility, and indications.
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key Try Dr. Kraus's MODALITY CHOICE IN THE ICU poll. This poll queries the physician and RN audience with regard to how often CRRT is used in their ICUs, what type of CRRT is chosen, how much replacement fluid is ordered, and what sort of anticoagulation is used.
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Updated: June 30, 2016 (Jun30)
Jun30 FDA issues warning about Shiga-toxin producing E. Coli found in flour
Apr13 New bacteria called Elizabethkingia affecting Midwest patients.
Feb29 Phage Therapy 2016 World Congress meets this June in Paris.
Dec14 Even more news on the new HDCN Facebook page!
Dec01 SecA inhibitors particularly effective against MRSA and other bacteria.
Nov24 Histone deacytelase (HDAC) inhibitors prevent muscle wasting.
Sep05 Multistate outbreak of salmonella linked to cucumbers.
Jun29 Drink when thirsty advice for athletes from Sports Medicine group
May12 Sedasys automated anesthesia delivery system replacing anesthesiologists for minor procedures.
May08 Putting the brakes on bacterial resistance to antibiotics with targeted antibiotic scheduling.
Apr23 Currently approved antihelminthic drug effective against MRSA
Feb26 AKI electronic alert system backfires and increases interventions without improving outcomes.
Feb20 Bourbon virus - a previously unknown Thogotovirus, associated with AKI after tick bite.
Jan24 FDA committee recommends approval of drug to treat invasive aspergillosis.
Jan09 New variant of aminoglycosides does not impair hearing.
Industry Advances Emphasis
archive
Clinical Trials, Surrogate Endpoints, and Clinical Experience (S. Chawla) ASN Renal Week 2008
Acute Coronary Syndromes and Arrhythmias (M. Hollenber) ASN Renal Week 2008
Acute Renal Failure: The Elderly Patient in the ICU and Other Scenarios (Himmelfarb) ASN Renal Week 2008
Pathophysiology of AKI (A. Molitoris) ASN Renal Week 2008
Hepatorenal Syndrome (A. Gonwa) ASN Renal Week 2008
Pediatric AKI (Goldstein) ASN Renal Week 2008
The Hybrid Renal Replacement Therapies (R. Marshall) ASN Renal Week 2008
Current State of Acute Brain Injury Management (R. Messe) ASN Renal Week 2008
Pediatric CRRT Conference Talks, 2006 (Neuhaus, Brophy, Gardner, Maxvold, Bunchman, Fishbach, Dodge-Khatami, Maggiori, Frey, Fischer, Ring, Ringe, Bonzel) PCRRT 2008 (PPT files)
Abdominal Compartment Syndrome (S. Chawla) ASN Renal Week 2008
Acute Lung Injury/ARDS (D. Liu) ASN Renal Week 2008
Ethics in the ICU: When Can You Say No? (Bekes) ASN Renal Week 2008
Hemodynamic Monitoring and Volume Management (Dellinger) ASN Renal Week 2008
Defining AKI (A. Kellum) ASN Renal Week 2008
Management of Renal Replacement Therapy in AKI (M. Palevsky) ASN Renal Week 2008
Contrast-Induced Nephropathy (D. Weisbord) ASN Renal Week 2008
Pharmacologic Therapy for AKI (T. Murray) ASN Renal Week 2008
Treatment of Poisonings (S. Goldfarb) ASN Renal Week 2008
Drug Dosing in AKI (A. Mueller) ASN Renal Week 2008
Ventilators and Pulmonary-Kidney Interactions (T. Murray) ASN Renal Week 2008
An Update on Congestive Heart Failure (K. Khush) ASN Renal Week 2008
Approach to Shock, Vasopressors, and Natriuretic Peptides (A. Kellum) ASN Renal Week 2008
Advances in the Treatment of Severe Sepsis and Septic Shock (E. Parrillo) ASN Renal Week 2008
Preoperative Risk Assessment (A. Golper) ASN Renal Week 2008
Infective Endocarditis in HD Patients (Salzer) ADC 2008
Overview of Gadolinium Contrast Agents and Recommendations for Screening (Kanal) ADC 2008
Acute Kidney Injury in the ICU: A Urea Kinetics Based Approach to Determine the Optimal Dialysis Dose (A Depner) ADC 2008
Use of Non-Heparin Anticoagulation in CRRT/SLED for the Critically Ill Patient (Fischer) ADC 2008
Acute Renal Replacement Therapy (Palevsky) ASN Board Review 2008
Controversy 1: Sodium Removal in APD:  There Is No Difference in Sodium Removal between APD and CAPD (Mujais) ADC 2008
Acute Kidney Injury in the ICU: When to Intervene with RRT (Palevski) ADC 2008
The Nephrologist’s Perspective on Nephrogenic Systemic Fibrosis (Abu-Alfa) ADC 2008
Potential interventions in sepsis-related acute renal failure (Ronco) RRI 2008
The Prognosis of Human AKI: Predictive Factors for Recovery and Progression (Himmelfarb) ASN Renal Week 2007
Ventilators 101: What the Non-Intensivist Needs to Know (T. Murray) ASN Renal Week 2007
Acute Kidney Injury. Congestive Heart Failure: A Nephrologist's Disease? (Murray) and AKI Therapeutics: From Bench to Commercialisation (Molitoris) (Murray, Molitoris) ASN Renal Week 2007
Advances in the Treatment of Severe Sepsis and Septic Shock (T. Murray) ASN Renal Week 2007
Using Biomarkers for AKI: What, How and When? (A. Molitoris) ASN Renal Week 2007
Evolving Conceptual Model for Human AKI (L. Mehta) ASN Renal Week 2007
An Update on Congestive Heart Failure (K. Khush) ASN Renal Week 2007
Immunomodulatory Cytokines in Human AKI (L. Jaber) ASN Renal Week 2007
Stem Cells and Renal Repair (Camussi) ASN Renal Week 2007
Approach to Shock, Vasopressors, and Natriuretic Peptides (D. Liu) ASN Renal Week 2007
Evolving Practices in the Management of AKI in the ICU (S. Chawla) ASN Renal Week 2007
Acute Lung Injury/ARDS (D. Liu) ASN Renal Week 2007
World-wide Practice of Extracorporeal Treatment of AKI (Ricci) ASN Renal Week 2007
Treatment of Poisonings (S. Goldfarb) ASN Renal Week 2007
Update in Coagulation: Cell Mediated Coagulation and New Anticoagulants (S. Chawla) ASN Renal Week 2007
Ethics in the ICU: When Can You Say No? (B. White) ASN Renal Week 2007
Technical Issues for the Delivery of RRT in the ICU (M. Palevsky) ASN Renal Week 2007
Hemodynamic Monitoring and Volume Management (S. Chawla) ASN Renal Week 2007
Pharmacologic Therapy for AKI (D. Okusa) ASN Renal Week 2007
Abdominal Compartment Syndrome (S. Chawla) ASN Renal Week 2007
Current State of Acute Brain Injury Management (Davenport) ASN Renal Week 2007
Defining AKI (L. Mehta) ASN Renal Week 2007
Treatment of AKI in Children: Conservative Management to RRT (E. Bunchman) ASN Renal Week 2007
Putting It All Together: Journal Club #1 (B. Leonard) ASN Renal Week 2007
Pathophysiology of AKI (A. Molitoris) ASN Renal Week 2007
Novel Therapeutics for Fluid and Electrolyte Disorders (Verbalis, Palmer) ASN Renal Week 2007
Contrast-Induced Nephropathy (M. Palevsky) ASN Renal Week 2007
Renal Replacement Therapy in AKI: When, What, and How Much (M. Palevsky) ASN Renal Week 2007
Pediatric AKI (Goldstein) ASN Renal Week 2007
Contrast Media and CKD: What You Should Know About Contrast-Induced Nephropathy and Nephrogenic Systemic Fibrosis (Persson, Knopp, Perazella) ASN Renal Week 2007
Role of Intensive Renal Replacement Therapy in AKI (A. Kellum) ASN Renal Week 2007
Drug Dosing in AKI (A. Mueller) ASN Renal Week 2007
Electrolyte/Acid-Base Emergencies in the ICU (Palmer) ASN Board Review 2007
Critical Care Nephrology (Murray) ASN Board Review 2007
Extracorporeal Therapy for Liver Support (Vienken) ADC 2007
Evidence-Based Indications for Plasmapheresis (Bargman) ADC 2007
Acute Renal Failure and Chronic Kidney Disease Following Liver Transplantation (Teitelbaum) ADC 2007
Hemodiafiltration (HDF) – A Critical Evaluation of its Value (Ronco) RRI 2006 - Part 2 (handouts)
ICU Nephrology and Acute Renal Failure: What the Nephrologist Must Know (Part 1 and 2) (Fuchs, Dellinger, Palevsky, Parillo, Hollenberg, Kasner, Bekes) ASN Renal Week 2005 (audiofiles)
Key Issues in Managing Acute Renal Failure (Molitoris, Palevsky, Schrier) ASN Renal Week 2005 (audiofiles)
Novel Technologies for Acute Renal Failure Therapeutic Discovery (Mehta, Molitoris, Portilla) ASN Renal Week 2005 (audiofiles)
ICU Nephrology and Acute Renal Failure: What the Nephrologist Must Know (Part 3 and 4) (Kellum, Molitoris, Okusa, Gines, Palevsky, Marshall, Tolwani, Goldstein, Mueller, Goldfarb) ASN Renal Week 2005 (audiofiles)
Hemodiafiltration (HDF): Theory, Quantification, Clinical Management (Canaud, Clark, Kjellstrand, Traeger, Akiba) ADC 2005 (audiofiles)
Acute Renal Failure (Safirstein Chugh, Depner, Ash, Ronco, Davenport, Friedman) ADC 2005 (audiofiles)
Renal replacement therapy for ARF in liver disease: Why, what, when and where (Gonwa) ASN 2002 Renal Week
Diagnosis, pathophysiology, and management of hepatorenal syndrome (Kupin) ASN 2002 Board Review Course
Dialysate selection in the dialysis unit (Gennari) RRI 2002 Int. Dialysis Conference
Herbs and the kidney: What to beware of (Debroe)

Early and Late Presentations of Ethylene Glycol Poisoning Am J Kidney Dis (Jun 2009)
Fluid, electrolyte and acid-base disorders associated with antibiotic therapy Nat Rev Nephrol (Apr 2009)
Dry-weight reduction in hypertensive hemodialysis patients (drip): a randomized, controlled trial Hypertens (Mar 2009)
Antiviral therapy for adults with chronic hepatitis B: a systematic review for a National Institutes of Health Consensus Development Conference Ann Intern Med (Jan 2009)
Clinical implications of disordered magnesium homeostasis in chronic renal failure and dialysis Semin Dial (Jan 2009)
National Institutes of Health Consensus Development Conference Statement: Management of hepatitis B Ann Intern Med (Jan 2009)
Infection associated with tunneled hemodialysis catheters Semin Dial (Dec 2008)
Biopsy conference: Intravascular hemolysis and acute renal failure after mitral and aortic valve repair Am J Kidney Dis (Nov 2008)
Coming clean: waterless hand cleaners -- which to choose? Am J Med (Oct 2008)
Adverse renal and metabolic effects associated with oral sodium phosphate bowel preparation Clin J Am Soc Nephrol (Sep 2008)
Balkan nephropathy: evolution of our knowledge Am J Kidney Dis (Sep 2008)
Balkan Nephropathy: Evolution of Our Knowledge (Bamias and Boletis) Am J Kidney Dis (Sep 2008)
Spurious Hyperphosphatemia in Patients on Hemodialysis With Catheters (Schiller et al) Am J Kidney Dis (Sep 2008)
Emergence of the concept of acute kidney injury Adv Chronic Kidney Dis (Jul 2008)
Noninvasive Coronary Artery Imaging: Magnetic Resonance Angiography and Multidetector Computed Tomography Angiography: (AHA Scientific Statement) Circulation (July 2008)
Contaminated heparin associated with adverse clinical events and activation of the contact system N Engl J Med (Jun 2008)
Hands-only (compression-only) cardiopulmonary resuscitation: a call to action for bystander response to adults who experience out-of- hospital sudden cardiac arrest: An AHA Science Advisory Circulation (Apr 2008)
Atherosclerotic renal artery stenosis: overtreated but underrated? J Am Soc Nephrol (Apr 2008)
Technology insight: biomarker development in acute kidney injury-what can we anticipate? Nature Clin Pract Nephrol (Mar 2008)
The Janus faces of allopurinol -- allopurinol hypersensitivity syndrome Am J Med (Mar 2008)
Beta-blockade in chronic dialysis patients Semin Dial (Feb 2008)
Cerebral salt wasting versus SIADH: What difference? J Am Soc Nephrol (Feb 2008)
Atheroembolic renal disease: A silent masquerader Kidney Int (Jan 2008)
What nephrologists need to know about gadolinium (Penfield et al) Nature Clin Pract Nephrol (Dec 2007)
Towards the incidence of acute phosphate nephropathy (Markowitz et al) J Am Soc Nephrol (Dec 2007)
Safety of magnetic resonance imaging in patients with cardiovascular devices: An American Heart Association Scientific Statement (Levin et al) Circulation (Dec 2007)
Incidence and clinical spectrum of thiazide-associated hypercalcemia (Wemers et al) Am J Med (Oct 2007)
Trainee Forum: Infective endocarditis in a hemodialysis patient: A dreaded complication (Schubert et al) Hemodial Int (Oct 2007)
Management of hyperkalemia in dialysis patients (Putcha et al) Semin Dial (Oct 2007)
New insights into nephrogenic systemic fibrosis (Swaminathan et al) J Amer Soc Nephrol (Oct 2007)
Prevention of Infective Endocarditis: Guidelines From the American Heart Association and other organizations (Wilson et al) Circulation (Oct 2007)
Clinical characteristics of patients with acute pulmonary embolism: data from PIOPED II (Stein et al) Am J Med (Oct 2007)
Use of the {delta}AG/{delta}HCO3- Ratio in the diagnosis of mixed acid-base disorders (Rastegar) J Am Soc Nephrol (Sep 2007)
Warfarin anticoagulation in hemodialysis patients: a systematic review of bleeding rates (Elliot) Am J Kidney Dis (Sep 2007)
Cisplatin nephropathy: is cytotoxicity avoidable? (Razzaque) Nephrol Dial Transplant (Aug 2007)
Hypophosphatemia: clinical consequences and management (Brunelli et al) J Am Soc Nephrol (Jul 2007)
Renal manifestations of plasma cell disorders (Leung et al) Am J Kidney Dis (Jul 2007)
Gadolinium-induced nephrogenic systemic fibrosis in patients with kidney disease (Perazella et al) Am J Med (Jul 2007)
Drug dosing considerations in alternative hemodialysis (Decker et al) Adv Chronic Kidney Dis (Jul 2007)
Impact of glucose levels on advanced glycation end products in hemodialysis (Godfrey) Hemodial Int (Jul 2007)
Contrast media nephropathy - how to diagnose and how to prevent? (Solomon) Nephrol Dial Transplant (Jul 2007)
Hospital-acquired hyponatremia - why are hypotonic parenteral fluids still being used? (Moritz et al) Nature Clin Pract Nephrol (Jul 2007)
Gadolinium use in patients with kidney disease: A cause for concern (Perazella et al) Semin Dial (Jun 2007)
Gadolinium use in patients with kidney disease: A cause for concern Semin Dial 05-07
CRRT Meeting 2007 abstracts Blood Purif (03-2007)
A case of nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis NCPN (02-2007)
Fluid balance, dry weight, and blood pressure in dialysis Hemodial Int 01-07
Serum anion gap: its uses and limitations in clinical medicine CJASN 01-07
Electrolyte disturbances in the intensive care unit (Sedlacek , Schoolwerth, Remillard) Sem Dial 12-06
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Dr. Michael Kraus, M.D.
Associate Professor of Medicine, Indiana University of School of Medicine, Indianapolis, IN