Palevsky

Acute Renal Failure - Pathogenesis, Diagnosis, and Therapy
(ASN Board Review, 2005). Part 1: How do we define acute renal failure (ARF)? What are the new RIFLE criteria? How do we diagnose ARF? How useful is the fractional excretion of urea? How does ARF impact on mortality? How do new theories of hepatorenal syndrome help us manage this condition? What is the abdominal compartment syndrome? How do we diagnose post-renal ARF? Interstitial nephritis? Acute vascular syndromes, and in particular, those due to atheroembolic disease?
Part 2: How does ATN present? You know about its 3 causes, but did you know about its 4 phases? Necrosis or apoptosis? What's the pathogenesis? How can renal inflammation associated with ATN affect distal organs like the heart? How can we prevent contrast nephropathy? Are low osmolar or iso-osmolar dyes useful? Is saline the gold standard? Is bicarbonate better? Can we reconcile all of the studies of N-acetylcysteine? What about fenoldopam? Theophylline? Preventive hemofiltration? Does low-dose dopamine have a role in ARF? Atrial natriuretic peptide? Are KIM-1 and NGAL of clinical use as novel markers of renal injury? Does early initiation of dialysis or CRRT help in ARF? What are the latest studies comparing intermittent HD with CRRT? What about PD and SLED? Membrane biocompatibility? More frequent (daily) intermittent dialysis? (more...)


key This quiz by Dr. Michael Kraus and Dr. Ed Sha deals with ANTICOAGULATION IN CRRT . It discusses the various anticoagulation methods available, their relative utility, and indications.
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key Try Dr. Kraus's MODALITY CHOICE IN THE ICU poll. This poll queries the physician and RN audience with regard to how often CRRT is used in their ICUs, what type of CRRT is chosen, how much replacement fluid is ordered, and what sort of anticoagulation is used.
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Updated: May 09, 2008 (M09)
M09 FDA reissues heparin alert, since contaminated heparin still stocked in a number of hospitals.
M07 New hospital superbug to worry about: Stenotrophomonas maltophilia
M05 ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
M02 Protozoans may ingest E. Coli, and carry them on the surface of vegetables like spinach and lettuce.
M01 MMWR: Acute renal failure associated with cosmetic soft tissue filler injections.
A28 New JAMA study to highlight CV risk of blood substitutes; FDA under renewed pressure.
A28 Hypertension seen in the emergency department frequently misattributed to trauma, stress, and not followed up.
A28 FDA approves Relistor (methylnaltrexone) for opioid-induced constipation.
A23 MIT led teams unravel heparin deaths mystery
A23 NEJM paper (full text) describes mechanism of how oversulfated chondroitin sulfate can cause anaphylaxis.
A23 FDA: Fatal hypoglycemia due to maltose-containing immune globulin causing erroneous blood glucose readings.
A22 FDA approves compact heart assist device from Thoratec.
A17 FDA critical path in process for evaluating biomarkers to detect kidney injury.
A15 FDA warns of selenium, chromium poisoning associated with health supplements.
A15 Archives Int Med: Loop diuretics associated with lower bone density in men.
Industry Advances Emphasis
archive
Pediatric CRRT Conference Talks, 2006 (Neuhaus, Brophy, Gardner, Maxvold, Bunchman, Fishbach, Dodge-Khatami, Maggiori, Frey, Fischer, Ring, Ringe, Bonzel) PCRRT 2006 (PPT files)
Hemodiafiltration (HDF) – A Critical Evaluation of its Value (Ronco) RRI 2006 - Part 2 (handouts)
Novel Technologies for Acute Renal Failure Therapeutic Discovery (Mehta, Molitoris, Portilla) ASN Renal Week 2005 (audiofiles)
Key Issues in Managing Acute Renal Failure (Molitoris, Palevsky, Schrier) ASN Renal Week 2005 (audiofiles)
ICU Nephrology and Acute Renal Failure: What the Nephrologist Must Know (Part 1 and 2) (Fuchs, Dellinger, Palevsky, Parillo, Hollenberg, Kasner, Bekes) ASN Renal Week 2005 (audiofiles)
ICU Nephrology and Acute Renal Failure: What the Nephrologist Must Know (Part 3 and 4) (Kellum, Molitoris, Okusa, Gines, Palevsky, Marshall, Tolwani, Goldstein, Mueller, Goldfarb) ASN Renal Week 2005 (audiofiles)
Hemodiafiltration (HDF): Theory, Quantification, Clinical Management (Canaud, Clark, Kjellstrand, Traeger, Akiba) ADC 2005 (audiofiles)
Acute Renal Failure (Safirstein Chugh, Depner, Ash, Ronco, Davenport, Friedman) ADC 2005 (audiofiles)
Renal replacement therapy for ARF in liver disease: Why, what, when and where (Gonwa) ASN 2002 Renal Week
Diagnosis, pathophysiology, and management of hepatorenal syndrome (Kupin) ASN 2002 Board Review Course
Dialysate selection in the dialysis unit (Gennari) RRI 2002 Int. Dialysis Conference
Herbs and the kidney: What to beware of (Debroe)

Gadolinium use in patients with kidney disease: A cause for concern Semin Dial 05-07
Serum anion gap: its uses and limitations in clinical medicine CJASN 01-07
Fluid balance, dry weight, and blood pressure in dialysis Hemodial Int 01-07
Electrolyte disturbances in the intensive care unit (Sedlacek , Schoolwerth, Remillard) Sem Dial 12-06
CRRT / ARF LINKS
ADQI
Eur Soc Int Care Med
CCM Society Links
San Diego Mtg - 2007
HDCN Topic Pages (KEY)
CRRT
Dialysis in ARF
Plasmapheresis
ARF etiology
ARF prevention
ARF treatment
ARF crystal-induced
ARF hypovolemic/septic
ARF drug-induced
ARF contrast
PEDIATRIC LINKS
PCRRT website

Dr. Michael Kraus, M.D.
Associate Professor of Medicine, Indiana University of School of Medicine, Indianapolis, IN