Palevsky

Acute Renal Failure - Pathogenesis, Diagnosis, and Therapy

(ASN Board Review, 2005). Part 1: How do we define acute renal failure (ARF)? What are the new RIFLE criteria? How do we diagnose ARF? How useful is the fractional excretion of urea? How does ARF impact on mortality? How do new theories of hepatorenal syndrome help us manage this condition? What is the abdominal compartment syndrome? How do we diagnose post-renal ARF? Interstitial nephritis? Acute vascular syndromes, and in particular, those due to atheroembolic disease?
Part 2: How does ATN present? You know about its 3 causes, but did you know about its 4 phases? Necrosis or apoptosis? What's the pathogenesis? How can renal inflammation associated with ATN affect distal organs like the heart? How can we prevent contrast nephropathy? Are low osmolar or iso-osmolar dyes useful? Is saline the gold standard? Is bicarbonate better? Can we reconcile all of the studies of N-acetylcysteine? What about fenoldopam? Theophylline? Preventive hemofiltration? Does low-dose dopamine have a role in ARF? Atrial natriuretic peptide? Are KIM-1 and NGAL of clinical use as novel markers of renal injury? Does early initiation of dialysis or CRRT help in ARF? What are the latest studies comparing intermittent HD with CRRT? What about PD and SLED? Membrane biocompatibility? More frequent (daily) intermittent dialysis? (more...)


key This quiz by Dr. Michael Kraus and Dr. Ed Sha deals with ANTICOAGULATION IN CRRT . It discusses the various anticoagulation methods available, their relative utility, and indications.
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key Try Dr. Kraus's MODALITY CHOICE IN THE ICU poll. This poll queries the physician and RN audience with regard to how often CRRT is used in their ICUs, what type of CRRT is chosen, how much replacement fluid is ordered, and what sort of anticoagulation is used.
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Updated: January 01, 2009 (J01)
J01 FDA and manufacturer warn or increased mortality risk in elderly patients with CKD treated with tinzaparin
D30 Scientists isolate genes that made 1918 flu lethal.
D26 New insights into how bacteria biofilm formation is triggered.
D18 Evidence mounts that probiotics may be useful to treat post-antibiotic diarrhea.
D13 Another FDA link regarding oral bowel preps.
D13 FDA alert regarding phosphate-containing oral bowel preps and new black box warning.
D11 FDA puts black box warning on phosphate-containing oral bowel prep drugs
D09 Fresenius' APP reassures about the safety of its heparin supply; launches heparin safety website.
D04 HALT-C trial shows absolutely no impact of interferon on progression of hepatitis C
D03 NEJM publishes case control study of allergic reactions due to OSCS-contaminated heparin.
N19 FDA advisory panel greenlights anti-MRSA antibiotic telavancin, but not approved by the FDA yet.
N18 CDC updates guidelines for disinfection and sterilization in health care facilities.
N18 Five days of cipro cause pervasive and persistent changes in gut microflora abundance.
N13 Catheter thermoablation of atrial fibrillation far superior to drug treatment.
N09 MP3 player earbuds should not be kept in shirt pockets in patients with pacemakers due to electrical interference.
Industry Advances Emphasis
archive
Pediatric CRRT Conference Talks, 2006 (Neuhaus, Brophy, Gardner, Maxvold, Bunchman, Fishbach, Dodge-Khatami, Maggiori, Frey, Fischer, Ring, Ringe, Bonzel) PCRRT 2006 (PPT files)
Hemodiafiltration (HDF) – A Critical Evaluation of its Value (Ronco) RRI 2006 - Part 2 (handouts)
Novel Technologies for Acute Renal Failure Therapeutic Discovery (Mehta, Molitoris, Portilla) ASN Renal Week 2005 (audiofiles)
Key Issues in Managing Acute Renal Failure (Molitoris, Palevsky, Schrier) ASN Renal Week 2005 (audiofiles)
ICU Nephrology and Acute Renal Failure: What the Nephrologist Must Know (Part 1 and 2) (Fuchs, Dellinger, Palevsky, Parillo, Hollenberg, Kasner, Bekes) ASN Renal Week 2005 (audiofiles)
ICU Nephrology and Acute Renal Failure: What the Nephrologist Must Know (Part 3 and 4) (Kellum, Molitoris, Okusa, Gines, Palevsky, Marshall, Tolwani, Goldstein, Mueller, Goldfarb) ASN Renal Week 2005 (audiofiles)
Hemodiafiltration (HDF): Theory, Quantification, Clinical Management (Canaud, Clark, Kjellstrand, Traeger, Akiba) ADC 2005 (audiofiles)
Acute Renal Failure (Safirstein Chugh, Depner, Ash, Ronco, Davenport, Friedman) ADC 2005 (audiofiles)
Renal replacement therapy for ARF in liver disease: Why, what, when and where (Gonwa) ASN 2002 Renal Week
Diagnosis, pathophysiology, and management of hepatorenal syndrome (Kupin) ASN 2002 Board Review Course
Dialysate selection in the dialysis unit (Gennari) RRI 2002 Int. Dialysis Conference
Herbs and the kidney: What to beware of (Debroe)

Balkan Nephropathy: Evolution of Our Knowledge (Bamias and Boletis) Am J Kidney Dis (Sep 2008)
Spurious Hyperphosphatemia in Patients on Hemodialysis With Catheters (Schiller et al) Am J Kidney Dis (Sep 2008)
Noninvasive Coronary Artery Imaging: Magnetic Resonance Angiography and Multidetector Computed Tomography Angiography: (AHA Scientific Statement) Circulation (July 2008)
Contaminated heparin associated with adverse clinical events and activation of the contact system N Engl J Med (Jun 2008)
Atherosclerotic renal artery stenosis: overtreated but underrated? J Am Soc Nephrol (Apr 2008)
Hands-only (compression-only) cardiopulmonary resuscitation: a call to action for bystander response to adults who experience out-of- hospital sudden cardiac arrest: An AHA Science Advisory Circulation (Apr 2008)
Technology insight: biomarker development in acute kidney injury-what can we anticipate? Nature Clin Pract Nephrol (Mar 2008)
The Janus faces of allopurinol -- allopurinol hypersensitivity syndrome Am J Med (Mar 2008)
Beta-blockade in chronic dialysis patients Semin Dial (Feb 2008)
Cerebral salt wasting versus SIADH: What difference? J Am Soc Nephrol (Feb 2008)
Atheroembolic renal disease: A silent masquerader Kidney Int (Jan 2008)
What nephrologists need to know about gadolinium (Penfield et al) Nature Clin Pract Nephrol (Dec 2007)
Towards the incidence of acute phosphate nephropathy (Markowitz et al) J Am Soc Nephrol (Dec 2007)
Safety of magnetic resonance imaging in patients with cardiovascular devices: An American Heart Association Scientific Statement (Levin et al) Circulation (Dec 2007)
Incidence and clinical spectrum of thiazide-associated hypercalcemia (Wemers et al) Am J Med (Oct 2007)
Trainee Forum: Infective endocarditis in a hemodialysis patient: A dreaded complication (Schubert et al) Hemodial Int (Oct 2007)
Management of hyperkalemia in dialysis patients (Putcha et al) Semin Dial (Oct 2007)
New insights into nephrogenic systemic fibrosis (Swaminathan et al) J Amer Soc Nephrol (Oct 2007)
Prevention of Infective Endocarditis: Guidelines From the American Heart Association and other organizations (Wilson et al) Circulation (Oct 2007)
Clinical characteristics of patients with acute pulmonary embolism: data from PIOPED II (Stein et al) Am J Med (Oct 2007)
Use of the {delta}AG/{delta}HCO3- Ratio in the diagnosis of mixed acid-base disorders (Rastegar) J Am Soc Nephrol (Sep 2007)
Warfarin anticoagulation in hemodialysis patients: a systematic review of bleeding rates (Elliot) Am J Kidney Dis (Sep 2007)
Cisplatin nephropathy: is cytotoxicity avoidable? (Razzaque) Nephrol Dial Transplant (Aug 2007)
Hospital-acquired hyponatremia - why are hypotonic parenteral fluids still being used? (Moritz et al) Nature Clin Pract Nephrol (Jul 2007)
Hypophosphatemia: clinical consequences and management (Brunelli et al) J Am Soc Nephrol (Jul 2007)
Renal manifestations of plasma cell disorders (Leung et al) Am J Kidney Dis (Jul 2007)
Gadolinium-induced nephrogenic systemic fibrosis in patients with kidney disease (Perazella et al) Am J Med (Jul 2007)
Drug dosing considerations in alternative hemodialysis (Decker et al) Adv Chronic Kidney Dis (Jul 2007)
Impact of glucose levels on advanced glycation end products in hemodialysis (Godfrey) Hemodial Int (Jul 2007)
Contrast media nephropathy - how to diagnose and how to prevent? (Solomon) Nephrol Dial Transplant (Jul 2007)
Gadolinium use in patients with kidney disease: A cause for concern (Perazella et al) Semin Dial (Jun 2007)
Gadolinium use in patients with kidney disease: A cause for concern Semin Dial 05-07
CRRT Meeting 2007 abstracts Blood Purif (03-2007)
A case of nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis NCPN (02-2007)
Serum anion gap: its uses and limitations in clinical medicine CJASN 01-07
Fluid balance, dry weight, and blood pressure in dialysis Hemodial Int 01-07
Electrolyte disturbances in the intensive care unit (Sedlacek , Schoolwerth, Remillard) Sem Dial 12-06
CRRT / ARF LINKS
ADQI
Eur Soc Int Care Med
CCM Society Links
San Diego Mtg - 2007
HDCN Topic Pages (KEY)
CRRT
Dialysis in ARF
Plasmapheresis
ARF etiology
ARF prevention
ARF treatment
ARF crystal-induced
ARF hypovolemic/septic
ARF drug-induced
ARF contrast
PEDIATRIC LINKS
PCRRT website

Dr. Michael Kraus, M.D.
Associate Professor of Medicine, Indiana University of School of Medicine, Indianapolis, IN