Griffin  

Beddhu  

The Year in Nephrology: Hypertension and Metabolic Renal Syndrome

Karen Griffin, MD, and Srinivasan Beddhu, MD
(ASN Renal Week Clinical Nephrology Conference Extract, November, 2008.)
Griffin: What do recent hard outcomes trials show about the benefits of treating hypertension? Why was the AASK trial not very convincing in terms of BP control? What is the evidence comparing different classes of anti-hypertensive agents? What can we learn from susceptibility to renal injury vs. BP curve analysis? Why is renal autoregulation important? When is renal autoregulation impaired? What is the potential risk of calcium channel blockers in this regard? What is behind the synergy of ACE inhibitor type drugs and diuretics? How can we safely use calcium channel blocking drugs in CKD patients, or can we? Beddhu: How do we define metabolic syndrome? What is its impact on progression of CKD. What is the impact of CKD on the cardiovascular effects of the metabolic syndrome? What are the therapeutic implications when confronted by a CKD patient with metabolic syndrome? How is adiponectin involved, both in nonuremic and CKD patients?
(more...)



Muntner

Fried

Renal Disease and the Metabolic Syndrome

Paul Muntner, PhD, and Linda F. Fried, MD, MPH
(ASN Renal Week Clinical Nephrology Conference, November, 2007.)
Muntner: How is metabolic syndrome defined and how do definitions vary among various organizations? What is its prevalence? How do individual components of metabolic syndrome associated with progression of CKD? What are the treatment options?
Fried: What is the evidence that statins reduce cardiovascular disease endpoints in CKD? What did the 4D study show and how cane these negative results in stage 5D patients be explained? Is there an increased risk of stroke with statins in stage 5D patients? In other patients? What is the effect of statins on progression of CKD? What are the possible mechanisms? Which types of CKD patients might be expected to get the most benefit from statins? Is there an increased risk of tubular proteinuria? (more...)




Froehlich

kay

Primary Care Issues in Nephrology: Peripheral Vascular Disease: Assessments and Approaches to Care (Froehlich); Rheumatology for Nephrologists (Kay).

James B. Froehlich, MD, MPH, and Jonathan Kay, MD
(ASN Renal Week Clinical Nephrology Conference, November, 2007.)
Froehlich: What are the risk factors for peripheral arterial disease (PAD) in the general population as well as in CKD patients? Who should be screened? What tests should be used for screening and diagnosis? What are the treatment options? Which drugs are useful? When is stenting indicated? Kay: What are the possible causes of monoarticular arthritis in CKD patients? Which crystals are involved? How does one treat inflammatory (rheumatoid) arthritis in CKD? How does beta-2- microglobulin disease present, and how can one treat it? What is new in terms of nephrogenic systemic fibrosis from a rheumatology perspective? (more...)

Updated: May 24, 2016 (May24)
May24 CRIC study shows a high urinary sodium excretion in CKD linked to higher CV risk.
Apr27 Tetraspanin-7 as an antibody target for type 1 diabete
Dec29 Novel methods to ensure viability of pancreatic islet cells for transplantation.
Dec29 Interleukin-17A may prevent and even reverse diabetic kidney injury.
Dec26 FGF21 suppresses cravings for sweets.
Dec14 Even more news on the new HDCN Facebook page!
Dec14 Some drugs cause weight gain by alterations in the gut microbiome.
Nov30 Combining fasting blood sugar with HbA1c best for detecting prediabetes.
Nov28 Immunotherapy for T1D focusing on regulatory T-cells shows promise.
Nov10 L-DOPA may delay onset of age-related macular degeneration by 8 years.
Sep25 Giving BP meds at bedtime particularly effective in lowering diabetes risk
Sep17 Empagliflozin use in diabetes associated with large reduction in CV risk.
Aug27 FDA approves 2nd PCSK9 inhibitor, Repatha, to lower LDL cholesterol
Aug14 Google partnering with Dexcom in continuous glucose monitoring device.
Jul08 Valsartan combined with sacubitril (neprilysin inhibitor) improves heart failure patient survival.
General Advances Emphasis
archive
Nephrology Roundtable: Glucose Transport and Targets for Intervention (De Zeeuw, Wright) ASN Renal Week 2008
Management of Glycemic Control (Mordes) ASN Renal Week 2008
Clinical: Therapeutic Initiatives in CVD in Diabetes (Pop-Busui) ASN Renal Week 2008
Diabetic Nephropathy and Aging Transformed Nephrology into a Geriatric Specialty (A. Friedman) ASN Renal Week 2008
Treatment and Pathology of Diabetic Nephropathy (Radhakrishnan) ASN Renal Week 2008
Basic: How Does Diabetes Enhance Cardiovascular Disease? (Goldberg) ASN Renal Week 2008
Case Summary - Questions & Answers (Pop-Busui) ASN Renal Week 2008
Metabolic Renal Syndrome (Beddh) ASN Renal Week 2008
The Year in Nephrology: Hypertension and Metabolic Renal Syndrome (Griffin, Beddhu) ASN Renal Week 2008
Metabolic Syndrome in PD (Li,) ADC 2008
Update on Teledialysis and the Problems with the Centers for Medicare and Medicaid Services (CMS) Reimbursement Guidelines (Moncrief) ADC 2008
KEYNOTE ADDRESS:The metabolic syndrome and kidney disease (Ritz) RRI 2008
How Do We Treat Patients with Diabetes and CKD in 2007? (G. Nelson) ASN Renal Week 2007
Metformin Revisited: Mechanisms of Endothelial Destruction (J. Mather) ASN Renal Week 2007
Genome Sequence Variation and the Inherited Basis of Type 2 Diabetes (Altshuler) ASN Renal Week 2007
Renal Disease and the Metabolic Syndrome (Muntner, Fried) ASN Renal Week 2007
Post Transplant Diabetes Mellitus (G. Cosio) ASN Renal Week 2007
Vitamin D Deficiency and Diabetes (Type 1 and Type 2) (Bouillon) ASN Renal Week 2007
Vascular Complications of Diabetes Microvascular Versus Macrovascular Complications (C. Rutledge) ASN Renal Week 2007
Urinary Protein Fragments and other Altered Protein Forms in Diabetic Nephropathy (B. Klein) ASN Renal Week 2007
The Measurement and Meaning of Growth Factors in the Urine (E. Gilbert) ASN Renal Week 2007
Sulodexide, Antifibrotics, AGE Inhibitors, and PKC Inhibitors (Sharma) ASN Renal Week 2007
Options for the Diabetic Renal Transplant Recipient (Pavlakis) ASN Renal Week 2007
New Treatments for Diabetes Mellitus: Implications for Clinicians (Nelson, Bakris) ASN Renal Week 2007
New Approaches to Diabetic Retinopathy (W. Gardner) ASN Renal Week 2007
Diabetic Neuropathy: Mechanisms and Management (L. Feldman) ASN Renal Week 2007
Advanced Glycation Endproduct and Oxidative Stress Biomarkers (R. Tuttle) ASN Renal Week 2007
PPAR Gamma and Thiazolidinediones (L. Bakris) ASN Renal Week 2007
Changing the fate of diabetics in the dialysis unit (Broumand) RRI 2007
Disease Management Actually Works in Dialysis Patients (Sands) RRI 2006, Part 2 (handouts)
Optimizing the Total Care of the Diabetic Patient with Kidney Disease - Lipids (Molitch) ASN Renal Week 2005
Coronary Angioplasty and Stenting: Indications and Results (Williams) ASN 2005 Renal Week
Emerging New Agents in Diabetic Kidney Disease (Lewis) ASN 2005 Renal Week
Newer Approaches to Diabetic Kidney Disease (Hollenberg, Lewis, Pavlakis) ASN Renal Week 2005 (audiofiles)
Novel Pathways for Prevention of Diabetes and Obesity-Related Renal and Vascular Disease (Cooper, Danesh) ASN Renal Week 2005 (audiofiles)
Obesity and the Kidney (Lord, Scherer, Fliser) ASN Renal Week 2005 (audiofiles)
Optimizing the Total Care of the Diabetic with Kidney Disease (McGill, Kaplan, Molitch, Williams) ASN Renal Week 2005 (audiofiles)
Diabetes and Dialysis (Oreopoulos, Friedman, Dasgupta, Kopple) ADC 2005 (audiofiles)
New Insights in the Pathogenesis of Uric Acid Nephrolithiasis (Sakhaee) ASN 2004
The Metabolic Syndrome and Kidney Disease: An Important Complication of Systemic Vascular Disease (Tuttle) ASN 2004

Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease Hypertens (Apr 2009)
The genetic basis of kidney disease risk in African Americans: MYH9 as a new candidate gene Am J Kidney Dis (Apr 2009)
Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis Am J Med (Mar 2009)
Aldosterone antagonists for preventing the progression of chronic kidney disease: a systematic review and meta-analysis Clin J Am Soc Nephrol (Mar 2009)
Is angiotensin-converting enzyme inhibitor and angiotensin receptor blocker combination therapy better than monotherapy and safe in patients with CKD? Am J Kidney Dis (Feb 2009)
Effect of a very low-protein diet on outcomes: long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study Am J Kidney Dis (Feb 2009)
More is not always better: intensive glycemic control in type 2 diabetes Am J Kidney Dis (Jan 2009)
Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the ADA and the Eur Assoc Study Diab Diabet Care (Jan 2009)
Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA Diabetes Trials: A position statement of the ADA, ACCF, and AHA. Diabet Care (Jan 2009)
Chronic kidney disease at high altitude J Am Soc Nephrol (Dec 2008)
Dual inhibition with losartan and aliskiren: a promising therapeutic option for type 2 diabetic nephropathy? Nature Clin Pract Nephrol (Dec 2008)
American College of Endocrinology Pre-Diabetes Consensus Conference: Part Three Diabet Care (Dec 2008)
Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies Am J Clin Nutr (Nov 2008)
American College of Endocrinology pre-diabetes consensus conference: part one Diabet Care (Oct 2008)
Passive smoking and risk of peripheral arterial disease and ischemic stroke in chinese women who never smoked Circulation (Oct 2008)
Glycated hemoglobin or glycated albumin for assessment of glycemic control in hemodialysis patients with diabetes? Nature Clin Pract Nephrol (Sep 2008)
Balkan nephropathy: evolution of our knowledge Am J Kidney Dis (Sep 2008)
Oral estrogen therapy in postmenopausal women is associated with loss of kidney function Kidney Int (Aug 2008)
Translating the A1C assay into estimated average glucose values Diabet Care (Aug 2008)
The aggravating mechanisms of aldosterone on kidney fibrosis J Am Soc Nephrol (Aug 2008)
Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the American Heart Association. Circulation (Jul 2008)
Population-based prevention of obesity: the need for comprehensive promotion of healthful eating, physical activity, and energy balance: A Scientific Statement From American Heart Association (Kumanyika SK et al) Circulation Jul 08
Population-based prevention of obesity: the need for comprehensive promotion of healthful eating, physical activity, and energy balance: A Scientific Statement From American Heart Association Circulation (Jul 2008)
Treating elderly people with diabetes and stages 3 and 4 chronic kidney disease Clin J Am Soc Nephrol (Jul 2008)
Debate: Weight loss and blood pressure control (Pro) vs. Dietary therapy for obesity: an emperor with no clothes (Con) Hypertens (Jun 2008)
Large artery stiffening with weight gain in humans: role of visceral fat accumulation Hypertens (Jun 2008)
Screening for Type 2 Diabetes Mellitus in Adults: U.S. Preventive Services Task Force Recommendation Statement Ann Intern Med (Jun 2008)
Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care Diabet Care (May 2008)
Screening for gestational diabetes mellitus: U.S. Preventive Services Task Force Recommendation Statement Ann Intern Med (May 2008)
Lipoprotein management in patients with cardiometabolic risk: Consensus statement from the American Diabetes Association and the American College of Cardiology Foundation Diabet Care (Apr 2008)
Hyperglycemia and acute coronary syndrome: A Scientific Statement From the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism Circulation (Mar 2008)
Adiponectin, cardiovascular function, and hypertension Hypertens (Jan 2008)
Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: Update regarding thiazolidinediones: a consensus statement from the ADA/EASD Diabet Care (Jan 2008)
Long term pharmacotherapy for obesity and overweight: updated meta-analysis (Rucker et al) Brit Med J (Dec 2007)
Rosiglitazone decreases albuminuria in type 2 diabetic patients (Miyazaki et al) Kidney Int (Dec 2007)
2007 Chronic angina focused update of the ACC/AHA 2002 Guidelines for the Management of Patients With Chronic Stable Angina: A Report of the ACC/AHA Task Force (Fraker Jr et al) Diabet Care (Dec 2007)
Obesity paradox in patients with hypertension and coronary artery disease (Lavie et al) Am J Med (Oct 2007)
Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review (Eurich et al) Brit Med J (Sep 2007)
Impact of glucose levels on advanced glycation end products in hemodialysis (Godfrey) Hemodial Int (Jul 2007)
Intensive versus moderate blood-pressure control in normotensive patients with type 2 diabetes (Briggs J) NCPN Jun 07
Hypomagnesemia in patients with type 2 diabetes CJASN 03-07
Hypomagnesemia in patients with type 2 diabetes (Pham et al) CJASN (03-2007)
KDOQI Clinical Practice Guidelines and CPRs (2006 update) for Treatment of Diabetes and CKD AJKD (Feb 07)
(2006 Pharma )Year in Review (Michele B. Kaufman, PharmD, RPh) Dial-Transplant 12-06
Advanced glycation end products and nephrotoxicity of high-protein diets (Uribarri, Tuttle) CJASN 11-06
ACE2: A new target for prevention of diabetic nephropathy? (Ingelfinger JR, commenting on an article by Batlle's group) JASN 11-06
Angiotensin-converting enzyme-2 (ACE-2) - a new player in the genesis of glomerular injury? (Comment by Ritz on paper by Oudit et al) JASN 10-06
Management of dyslipidemias in patients with diabetes and chronic kidney disease (Molitch). CJASN 09-06
KDOQI
Diabetes and CKD, 2006 update
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