Foley  

Sica  

Pathogenesis and Management of Cardiovascular Disease (CVD) in Chronic Kidney Disease
Robert N. Foley, MD, and Domenic A. Sica, MD. (ASN Renal Week, 2006). Foley: How are classic and novel risk factors related to outcome in CKD patients as well as in dialysis patients? What can we learn from Framingham data? From NHANES? Which of the classical risk factors works in the opposite direction when GFR is low? To what extent have patients with mild-moderate CKD been excluded from the major cardiovascular trials? What can we learn from analysis of these subsets? How do the observational data differ from randomized, controlled trials?
Sica: How are the pathogenses of CKD and CVD (cardiovascular disease) related? Where do both impact the RAS (renin-angiotensin system)? How does ACE inhibition affect different parts of the cardiovascular system? What conclusions can we draw from AASK? How can we rationally choose drugs from different classes to treat hypertension? How should different calcium-blockers and ACE inhibitors be used in CKD? How do ACE inhibitors and ARBs compare? (ASN Renal Week Official Symposium, 2006).
(more...)



Townsend  

Secondary Hypertension, including Chronic Kidney Disease
Ray Townsend, MD. (ASN Board Review Course, 2006). Townsend: Renin system activation, mineralocorticoid excess states, pheo, aortic coarctation, and primary renal disease are the main types. What is the best means to diagnose renovascular HTN? What are less common types of RV HTN? How do we approach low renin, high aldo HTN? What are diagnostic criteria (aldo/renin ratios, urinary aldos, etc.), and what are the treatment options besides surgery? How do we approach Cushing's, pheo, and hyper- and hypothyroidism and HTN? What are the main genetic disorders? Liddle, GRH, activating MR receptor mutations, and 11-beta-hydroxysteroid dehydrogenase? What is Gordon's syndrome? What are the main drug-induced causes, including anti-angiogenesis agents? What's new in treating HTN associated with CKD?
(more...)



White  

Calhoun  

Cosio  

Resistant Hypertension: Reducing Cardiovascular Events
(ASN Renal Week Official Symposium. November, 2005, Philadelphia, PA)
White: During introductory remarks, two cases of resistant hypertension are presented to set the stage. A young woman who works in a hospital on 3 drugs with BP 160/100, and an elderly retiree who finds that his AM BP is quite elevated on home monitoring. Calhoun: What is the prevalence of primarly aldosteronism in hypertensives, and how does this depend on the resistance of hypertension to treatment? What percent of hypertension is low-renin. To what degree does resistant hypertension respond to aldosterone blockers, and does this depend on aldosterone excretion rates? How are high-aldosterone hypertensives different from those with normal aldo levels in terms of endothelial dilation, LVH, and other measures? How can aldosterone blockade as well as salt intake modify endothelial vasodilatory capacity and LVH? White: In resistant hypertension, what other drugs can we use? How do CCB/ACE combos compare to BB/D? What dose of diuretic should be added to an ACE/ARB regimen? Is ARB half-life important? What are new drugs on the horizon? Cosio: What should target LDL-C (LDL cholesterol) levels be for CKD patients? How do CV risk factors cluster in CKD patients? Which dyslipidemias are associated with increased risk? How can one treat low HDL-cholesterol? What did the ALERT and 4-D trials show? How do we explain the negative results of the 4-D trial?
(more...)
Updated: September 05, 2008 (S05)
S05 Photographing what they eat helps dieters stick to weight-loss plans and identifies bingeing.
S02 Want to live longer? Take the stairs instead of the elevator.
A29 Singh and Furberg editorialize against use of thiazolidinediones due to CV risk and lack of CV benefit.
A29 100g/day of dark chocolate lowers blood pressure by 3 mm Hg.
A27 Debate flares: Can obese patients be healthy?
A26 Allopurinol lowers blood pressure in hypertensive adolescents
A26 Newer gated CT scans diagnose coronary artery disease and obviate need for angiography.
A22 Some evidence that Vytorin is, or maybe is not, associated with an increased cancer risk; FDA gets involved.
A21 AMAG receives fast track designation from FDA for ferumoxytol as an MRI contrast agent.
A19 Lowering homocysteine with folic acid and B vitamins fails to reduce CV events in heart disease patients.
A19 Obesity epidemic due to increased food intake, and not decreased activity level.
A15 When is a potential heart donor really dead? NEJM report raises some ethical questions.
A15 Lancet: ONTARGET study shows mixed results for combined ARB/ACEI therapy; greater reduction of proteinuria but a higher renal event rate.
A15 Bariatric surgery - induced weight loss helps, but does not cure, sleep apnea.
A13 Enhancing lysosomal receptors for chaperone molecules prevents aging of mouse livers.
Industry Advances Emphasis
archive
Secondary Hypertension, including Chronic Kidney Disease ASN Board Review 2006
Pathogenesis and Management of Cardiovascular Disease (CVD) in Chronic Kidney Disease ASN Renal Week 2006
Update on Vascular Calcification in Chronic Kidney Disease (CKD) Patients (Isaac Teitelbaum, MD; Robert Toto, MD; Dennis Andress, MD; Gerard M. London, MD) ADC 2006 (audio only)
Emerging New Agents in Diabetic Kidney Disease (Lewis) ASN 2005 Renal Week
Coronary Angioplasty and Stenting: Indications and Results (Williams) ASN 2005 Renal Week
Webcasts from the ISH 2006 meeting in Fukuoka, Japan, October, 2006 (ISH 2006) ADC 2006 (audiofiles)
Blood Pressure on Dialysis (Kalantar-Zadeh, Reams, Misra, Sherman, Charra) ADC 2006 (audiofiles)
Uric acid as a Uremic Toxin (Ikizler, Nakagawa) RRI 2006, Part 2 (handouts)
Sodium as a Uremic Toxin (Ritz) RRI 2006, Part 2 (handouts)
Kidneys, Hearts, Hormones, Immunomodulators and More: Complex Systems Requiring Integrated Understandings (Adeera Levin) RRI 2006, Part 2 (handouts)
Cardiovascular Disease Causes and Consequences of Sympathetic Hyperactivity in CKD (Kotanko) RRI 2006, Part 3 (handouts)
Dry Weight Assessment and Rebound (Kuhlmann, Greenwood) RRI 2006, Part 3 (handouts)
Resistant Hypertension: Reducing Cardiovascular Events (White, Calhoun, Cosio) ASN Renal Week 2005
Hypertensive Urgencies and Emergencies: Clinical Syndromes And Therapy (Textor) ASN Renal Week 2005
Pathogenic Mechanisms of Ischemic Nephropathy (Lerman, Navar, Wilcox, Julliard) ASN Renal Week 2005 (audiofiles)
Inflammation, Dyslipidemia and the Kidney (Massy, Tonelli, Danovitch, Kasiske, Landray) ASN Renal Week 2005 (audiofiles)
Refractory Hypertension: Pathogenesis, Diagnosis and Therapy (Townsend, Norris, Sica) ASN Renal Week 2005 (audiofiles)
Childhood Hypertension: The View in 2005 (Flynn, Bertram, Portman) ASN Renal Week 2005 (audiofiles)
Genetic Hypertension and the Cortical Collecting Duct (CCD): What Every Nephrologist Must Know! (Ferrari, Luft, Geller, Auchus) ASN Renal Week 2005 (audiofiles)
Kidney-Heart Interactions (Pfeffer, Ritz, Burnett) ASN Renal Week 2005 (audiofiles)
Aldosterone, Resistant Hypertension and Target Organ Injury (Calhoun, Goodfriend, Weber, Geller) ASN Renal Week 2005 (audiofiles)
Cardiovascular Risk Factors and Renal Disease (Vaziri, Bostom, Hsueh) ASN Renal Week 2005 (audiofiles)
Emerging Concepts in Cardiovascular Disease (Stenvinkel, Moe) ASN Renal Week 2005 (audiofiles)
Treatment of Hypertension in CKD (Adler, Toto, Levin, Peixoto, Weir) ASN Renal Week 2005 (audiofiles)
Influence of Lifestyle on Hypertension, CKD, and CVD (Kramer, Tuttle) ASN Renal Week 2005 (audiofiles)
Secondary Hypertension (Gomez-Sanchez, Dworkin, Toto) ASN Renal Week 2005 (audiofiles)
The Heart on Dialysis (Part 1) (Kalantar-Zadeh, Aggarwal, Kopple, Saran) ADC 2005 (audiofiles)
Hypertension, CKD, and CVD Risks (Moe, London, Sarnak) ADC 2005 (audiofiles)
Hypertension in Special Populations (Portman, Izzo, Norris, August, Sarnak) ADC 2005 (audiofiles)
The Heart on Dialysis (Part 2) (Beddhu, Amerling, Sherman, Misra, Herzog) ADC 2005 (audiofiles)
Controlling Volume Status and Blood Pressure in PD Patients (Faber, Selgas, Rippe) ADC 2005 (audiofiles)
The Unexplained Relationship of Blood Pressure to Survival in the Dialysis Patient: A New Explanation (Saran) RRI 2005 (audiofiles)
The Impact of Post-Dialysis Weight on Patient Outcomes in Hemodialysis (Charra) RRI 2005 (audiofiles)
Renin-Angiotensin System Actions and Interactions in CKD (Anderson) ASN 2004
New Insights in the Pathogenesis of Uric Acid Nephrolithiasis (Sakhaee) ASN 2004
When and How to Use the Selective Aldosterone Receptor Antagonists to Optimize Cardiorenal Event Reduction (Bakris) ASN 2004
Secondary Hypertension Including Chronic Kidney Disease (Toto) ASN Board Review 2004
Uric acid, the kidney, and the pathogenesis of hypertension. Two parts. (Johnson) ASN Renal Week
Therapy in ischemic nephropathy : A data based approach (Textor) ASN Renal Week
Role of the sympathetic nervous system in the control of hypertension (Campese) ASN 2002 Renal Week
Renal autoregulation and hypertension injury: Do all agents that lower blood pressure protect the kidney? (Griffin) ASN 2002 Renal Week
Ideal actions of anti-hypertensive drugs (Ruilope) ASN 2002 Renal Week
The Malnutrition - Inflammation - Atherosclerosis or MIA syndrome (Stenvinkel) ASN 2002 Renal Week
Microalbuminuria: The kidney's message about the systemic vasculature (Tuttle) ASN 2002 Renal Week
Treatment of hypertension in renal parenchymal disease (Bakris) ASN 2002 Board Review Course
How to reduce CV risk in the patient with chronic kidney disease (Culleton) NKF 2002 Spring Meeting
How do calcium/phosphorus abnormalities contribute to CV risk? (Goodman) NKF 2002 Spring Meeting
Current concepts in the diagnosis and management of pediatric hypertension (Portman) NKF 2002 Spring Meeting
Aldosterone, salt and cardiac fibrosis (Funder)

Cholesteryl Ester Transfer Protein Inhibition for Coronary Heart Disease Prevention: Real Hope or Despair? (Frishman WH and Barkowski RS) Am J Med (Aug 2008)
Oral estrogen therapy in postmenopausal women is associated with loss of kidney function Kidney Int - Aug - 08
Exercise in Dialysis Patients: A Review (Johansen K) Hemodial Int - Jul - 08
Population-based prevention of obesity: the need for comprehensive promotion of healthful eating, physical activity, and energy balance: A Scientific Statement From American Heart Association (Kumanyika SK et al) Circulation Jul 08
Dyslipidemia in CKD: An approach to pathogenesis and treatment. (Tsimihodimos) (Am J Nephrol Jul 2008)
Resistant hypertension: diagnosis, evaluation, and treatment Circulation (Jul 2008)
Treating elderly people with diabetes and stages 3 and 4 chronic kidney disease CJASN (Jul 2008)
Abrupt shift of the pattern of diurnal variation in stroke onset with daylight saving time transitions (Foerch C et al) Circulation - Jul 08
Dietary sodium and cardiovascular and renal disease risk factors: dark horse or phantom entry? (McCarron DA) NDT Jul 08
Noninvasive Coronary Artery Imaging: Magnetic Resonance Angiography and Multidetector Computed Tomography Angiography: (AHA Scientific Statement) Circulation (July 2008)
Lipid abnormalities and cardiovascular risk in renal disease J Am Soc Nephrol (Jun 2008)
Should patients with venous thromboembolism be screened for thrombophilia? Am J Med (Jun 2008)
Pleiotropic effects of telmisartan: still more to come? J Hypertens (May 2008)
Prevention of heart failure: a scientific statement from the American Heart Association Councils Circulation (May 2008)
Efficacy and safety of fondaparinux and enoxaparin for acute coronary syndromes in CKD Am J Kidney Dis (May 2008)
ACC/AHA/HRS 2008 Guidelines for device-based therapy of cardiac rhythm abnormalities Circulation (May 2008)
Targeting proteinuria as a valid surrogate for individualized kidney protective therapy Am J Kidney Dis (May 2008)
Lipoprotein management in patients with cardiometabolic risk: Consensus statement from the American Diabetes Association and the American College of Cardiology Foundation Diabet Care (Apr 2008)
Effect of the Italian smoking ban on population rates of acute coronary events Circulation (Mar 2008)
Revisiting the dialysate sodium prescription as a tool for better blood pressure and interdialytic weight gain management in hemodialysis patients Clin J Am Soc Nephrol (Mar 2008)
Achieving blood pressure targets during dialysis improves control but increases intradialytic hypotension Kidney Int (Mar 2008)
Systolic hypertension in the elderly: addressing an unmet need Am J Med (Mar 2008)
Supratherapeutic doses of angiotensin receptor blockers to decrease proteinuria in patients with chronic kidney disease Am J Nephrol (Mar 2008)
Hyperglycemia and acute coronary syndrome: A Scientific Statement From the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism Circulation (Mar 2008)
Rationale for combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor treatment and end-organ protection in patients with chronic kidney disease Am J Nephrol (Mar 2008)
Association between obesity and kidney disease: A systematic review and meta-analysis Kidney Int (Jan 2008)
Beta-blockade in chronic dialysis patients Semin Dial (Feb 2008)
Mechanisms of vascular calcification in chronic kidney disease J Am Soc Nephrol (Feb 2008)
Renal and cardiac effects of antihypertensive treatment with ramipril vs metoprolol in autosomal dominant polycystic kidney disease Nephrol Dial Transplant (Feb 2008)
2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention Circulation (Jan 2008)
Poor correlation between coronary artery calcification and obstructive coronary artery disease in an end-stage renal disease patient Hemodial Int (Jan 2008)
Atheroembolic renal disease: A silent masquerader Kidney Int (Jan 2008)
2007 Chronic angina focused update of the ACC/AHA 2002 Guidelines for the Management of Patients With Chronic Stable Angina: A Report of the ACC/AHA Task Force (Fraker Jr et al) Diabet Care (Dec 2007)
Long term pharmacotherapy for obesity and overweight: updated meta-analysis (Rucker et al) Brit Med J (Dec 2007)
Evidence for the Reaffirmation of the U.S. Preventive Services Task Force Recommendation on Screening for High Blood Pressure (Wolff et al) Ann Intern Med (Dec 2007
Safety of magnetic resonance imaging in patients with cardiovascular devices: An American Heart Association Scientific Statement (Levin et al) Circulation (Dec 2007)
Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia (Reungjui et al) Kidney Int (Dec 2007)
Hypertension in pregnancy: an emerging risk factor for cardiovascular disease (Garovic et al) Nature Clin Pract Nephrol (Nov 2007)
Inherited arrhythmias: A National Heart, Lung, and Blood Institute and Office of Rare Diseases Workshop Consensus Report (Lenhart et al) Circulation (Nov 2007)
The pivotal role of sodium balance in control of blood pressure in dialysis patients (Tomson et al) Hemodial Int (Nov 2007)
The 2007 revised ESC/ESH Guidelines in the management of hypertension: clarifying individual patient care (MacFayden) J Hum Hypertens (Oct 2007)
Resistant hypertension and aldosterone excess: new insights from ambulatory blood pressure monitoring (Grassi et al) J Hypertens (Oct 2007)
Obesity paradox in patients with hypertension and coronary artery disease (Lavie et al) Am J Med (Oct 2007)
ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery (Fleisher et al) Circulation (Oct 2007)
Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non-ST-segment-elevation acute coronary syndrome (Scirica et al) Circulation (Oct 2007)
Treatment of microalbuminuria in hypertensive subjects with elevated cardiovascular risk: Results of the IMPROVE trial (Bakris et al) Kidney Int (Oct 2007)
Prevention of Infective Endocarditis: Guidelines From the American Heart Association and other organizations (Wilson et al) Circulation (Oct 2007)
Cardiac troponin assays: a view from the clinical chemistry laboratory (Melanson et al) Circulation (Oct 2007)
Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis (Chong et al) Brit Med J (Oct 2007)
Peripheral artery disease and hypertension: the relation between ankle-brachial index and mortality (Karthikeyan et al) J Hum Hypertens (Oct 2007)
Is there an unrecognized epidemic of primary aldosteronism? (debate) (Calhoun & Kaplan) Hypertens (Sep 2007)
Warfarin anticoagulation in hemodialysis patients: a systematic review of bleeding rates (Elliot) Am J Kidney Dis (Sep 2007)
High salt intake: a cause of blood pressure-independent left ventricular hypertrophy? (Burnier et al) Nephrol Dial Transplat (Sep 2007)
Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review (Eurich et al) Brit Med J (Sep 2007)
Association of antihypertensive therapy and diastolic hypotension in chronic kidney disease (Peralta et al) Hypertens (Sep 2007)
Independent impact of gout on mortality and risk for coronary heart disease (Choic et al) Circulation (Aug 2007)
ACC/AHA 2007 Guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction Circulation (Aug 2007)
What adult nephrologists should know about childhood blood pressure (Hadstein et al) Nephrol Dial Transplant (Aug 2007)
Prophylactic anticoagulation in nephrotic syndrome: a clinical conundrum (Glassock) J Am Soc Nephrol (Aug 2007)
Physical activity and public health in older adults Circulation (Aug 2007)
The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio (Hood et al) Adv Chronic Kidney Dis (Jul 2007)
The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) Double-Blind Crossover Trial in Patients With Low-Renin Hypertension and Elevated Aldosterone-Renin Ratio (Hood SJ et al) Circulation (Jul 07)
Influence of acute and chronic mineralocorticoid excess on endothelial function in healthy men (Nietlispach et al) Hypertens (Jul 2007)
Are we overestimating left ventricular abnormalities in end- stage renal disease? (Mark et al) Nephrol Dial Transplan (Jul 2007)
Pulse wave velocity is inversely related to vertebral bone density in hemodialysis patients (Raggi et al) Hypertens (Jun 2007)
A young woman with neurofibromatosis and severe hypertension (Gold et al) Am J Med (Jun 2007)
A different approach to resistant hypertension (Hirsch S) Cleveland Clinic J Med (Jun 07)
Intensive versus moderate blood-pressure control in normotensive patients with type 2 diabetes (Briggs J) NCPN Jun 07
Treatment of hypertension in the prevention and management of ischemic heart disease: A Scientific Statement From the American Heart Association Council for High Blood Pressure et al (O'Gara et al) Circulation (May 2007)
Pathophysiology of the clinical manifestations of preeclampsia (Hladunevich et al) Clin J Am Soc Nephrol (May 2007)
Controveries in renal artery stenosis: A review by the American Society of Nephrology Advisory Group on Hypertension (Levin et al) Am J Nephrol 04-07
Controveries in renal artery stenosis: A review by the American Society of Nephrology Advisory Group on Hypertension (Levin A et al) Am J Nephrol (04-2007)
Lipoprotein metabolism and lipid management in chronic kidney disease JASN 04-07
ACCF/AHA 2007 Clinical Expert Consensus Document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain. Circulation (02-07)
Effectiveness of Management Strategies for Renal Artery Stenosis: A Systematic Review (Balk et al) Annals Intern Med 12-06
Physical Activity Intervention Studies: What We Know and What We Need to Know (AHA) Circulation 12-06
Aldosterone and Cardiovascular Disease. Smoke and Fire (Calhoun). Circulation 12-06
Obesity: Growing Impact on CKD (McGill, Furth, Kaskel) Adv Chronic Kidney Dis 10-06
Angiotensin-converting enzyme-2 (ACE-2) - a new player in the genesis of glomerular injury? (Comment by Ritz on paper by Oudit et al) JASN 10-06
Management of dyslipidemias in patients with diabetes and chronic kidney disease (Molitch). CJASN 09-06
HYPERTENSION GUIDELINES
K-DOQI Lipid Guidelines
JNC 7
HTN in Pregnancy
ADA Clinical Practice Recs
Canadian Lifestyle Guidelines
Salt Reduction Guide
DASH Diet Facts
Guidelines.gov
Renovascular HTN (Nuc Med)
HDCN Topic Pages (KEY)
Ambulatory BP Monitoring
Arm Cuff Measurement
ACEI, AII Blockers
Beta Blockers
Ca Antagonists
Beta Blockers
Heart in HTN
Kidney in HTN
Genetics
Hormonal Physiology
Inflammatory Syndrome
Salt Sensitivity
Outcomes
Elderly
Endocrine
Syndrome X, Diabetes
Lipid Disorders
Smoking
Renovascular
HTN in Women
PATIENT LINKS, TRIALS
American Heart Assoc
National Stroke Assoc
NHLBI
Clinical Trials (NIH)
CV Risk Calculator

Dr. Carmine Zoccali, M.D.
Postgraduate Professor of Nephrology, Director, Center for Clinical Physiology, Renal Diseases and Hypertension of the Italian Research Council, Reggio Calabria, Italy (European Editor)