Columbia University

Biopsy Conference: A middle-aged male with new onset nephrotic syndrome
(Columbia University Nephrology and Pathology Faculty; January, 2007)

A middle-aged male had hyperlipidemia, heavy smoking history, hypovitaminosis D, no DM, no HTN, no family history of renal disease. Taking furosemide, simvastatin, lisinopril, vitamin D. Presents with pedal edema and 13g/day proteinuria. Serum albumin is 2.2 g/dL. Complements and serologies are normal. Is it membranous GN? FSGS? Minimal change disease? Amyloidosis? Discussion focus: Thin basement nephropathy and membranous nephropathy.
(Edited by Jai Radhakrishnan, MD). (more...)



Walker

Membranoproliferative Glomerulonephritis Pathology Update
(Patrick D. Walker, MD; Renal Week 2005)

What is the history of MPGN and how were the various subtypes characterized and recognized? What is the light, IF, and electron microscopy of type 1 MPGN? What are the three groups of type III MPGN? What is Juvenile Acute Non-Proliferative GN (JANG)? What is new about Dense Deposit Disease (type II)? What are the subcategories of DDD and what implications does this have for treatment? Why is DDD not MPGN? (more...)

Updated: May 05, 2008 (M05)
M05 ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
A29 Rituxan fails as lupus treatment in controlled trial.
A29 Jund, a gene that regulates activity of macrophages, linked to kidney inflammation.
A24 GAO says that FDA lacks resources to inspect non-US drug suppliers; only 8% are being inspected now.
A12 Once yearly zoledronic acid increases lumbar spine density by 4% in glucocorticoid-induced osteoporosis patients; better than risedronate
A10 FDA communication regarding CellCept and Myfortic (mycophenolate) - ongoing safety review.
A10 FDA notice regarding investigation of mycophenolate mofetil regarding progressive multifocal leukoencephalopathy.
M31 Mysterious periodic fevers in children cured by tonsillectomy.
M19 New camera with multiple lenses will be able to take detailed 3-D photographs.
M12 New macrophage-related protein implicated in inflammatory disease.
M06 Lupus foundation sponsored webchat about lupus and kidney disease scheduled for Wednesday, March 14th.
F23 Making heparin is a dirty job
F12 Embryonic stem cells can be used to create fully functioning immune cells.
F11 Integrin receptor linked to HIV infection and replication in the gut. Is a treatment already available?
J21 Anti-TNF compounds as well as rituximab, disrupt lymph node germinal centers.
General Advances Emphasis
archive
Membranoproliferative Glomerulonephritis Pathology Update (Walker) ASN 2005 Renal Week
Membranoproliferative Glomerulonephritis: Clinical Spectrum (Glassock) ASN 2005 Renal Week
The Role of Podocytes in Proteinuria and Progressive Renal Disease (Kriz, Salant) ASN 2005 Renal Week (audiofiles)
New Insights in IgA Nephropathy (Haas, Monteiro, Feehally, Hsu) ASN 2005 Renal Week (audiofiles)
Antibody Mediated Responses in Allo and Autoimmunity (Wasowska) ASN 2005 Renal Week (audiofiles)
Renal Biopsy: Clinical Correlations (Walker, Smith, Chander, Barisoni) ASN 2005 Renal Week (audiofiles)
Non-Amyloid Dysproteinemias and the Kidney (Ronco, Korbet, Madore) ASN 2005 Renal Week (audiofiles)
Issues in Lupus Nephritis (Rifkin, Levine, Austin Appel) ASN 2005 Renal Week (audiofiles)
Management Issues in Systemic Lupus Erythematosus (Austin, Parfrey, Cohen) ASN 2005 Renal Week (audiofiles)
Renal Amyloidosis: Pathogenesis, Diagnosis, and Therapy (Benson, Herrera, Seldin) ASN 2005 Renal Week (audiofiles)
Progression and Treatment of Fibrosis (Bissell) ASN 2005 Renal Week (audiofiles)
Collapsing Glomerulopathy - A Distinct Pathogenic Entity (Barisoni, Kopp, Nelson) ASN 2005 Renal Week (audiofiles)
Basic Science for Clinical Nephrologists - Mechanisms of Injury in Glomerulonephritis: A Review and Update (Julian, VanderWoude, Botto) ASN 2005 Renal Week (audiofiles)
Why is TNF a Good Therapeutic Target? (Feldman) ASN 2005 Renal Week (audiofiles)
Glomerulonephritis Update: Diagnosis and Therapy (Part 1 and 2) (Appel, Rennke, Cattran, Falk, Korbet, Glassock) ASN 2005 Renal Week (audiofiles)
Glomerulonephritis Update: Diagnosis and Therapy (Part 3 and 4) (Falk, Pusey, Appel, Korbet, Kupin, Charytan) ASN 2005 Renal Week (audiofiles)
Infectious Diseases After Immunosuppression in the Non-Transplant Kidney Patient Population (Brennan) ASN 2004 Renal Week
Non-Standard Therapy in Membranous Nephropathy (Remuzzi) ASN 2004 Renal Week
Therapy of ANCA-Associated Vasculitis and EUVAS Trials (Jayne) ASN 2004 Renal Week
ANCA-associated RPGN: Role of Plasmapheresis (Pusey) ASN 2004 Renal Week
Indications for Immunosuppression in Membranous Nephropathy (Cattran) ASN 2004 Renal Week
Advances in the Treatment of Focal Glomerulosclerosis (FSGS) (Kaskel) ASN 2004 Renal Week

Why are rheumatologists treating lupus nephritis? (Bargman JM) NCPN Jun 07
Pathogenesis and prevention of bone loss in patients who have kidney disease and receive long-term immunosuppression. JASN (01-07)
Lupus nephritis: Toll the trigger! (KD Smith, commenting on a study by Pawar et al). JASN 12-06
Recurrent glomerulonephritis after kidney transplantation (Choy, Chan, Lai) Am J Transplant 11-06
Glomerulonephritis Links
GENERAL
Am Coll Rheumatology
Arthritis Foundation
Clinical Trials.gov
CenterWatch trial list
LUPUS
Lupus Foundation
NIAMS Lupus Patient info
Wegener's
Wegener Foundation
FSGS
NephCure Foundation
Vasculitis
INSSYS
Cleveland Clinic Vasculitis Ctr
Johns Hopkins
Pathology
Atlas Renal Pathology
HDCN Topic Pages (KEY)
Acute GN/RPGN
HUS/TTP
Acute interstitial
Pyelonephritis
Myeloma
Dx Proteinuria
Biopsy tips
Dx Hematuria

Minimal change
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Membranous
Amyloid
Membranoproliferative
IgAN
Henoch-Schönlein
Lupus
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Hepatitis
HIVAN et al
Other infections
NSAIDS et al
Vasculitis / ANCA
Hereditary
NS etiology, complications
NS adjunct Rx