A RANDOMISED TRIAL OF DIFFERENT RENAL REPLACEMENT MODALITIES IN ACUTE RENAL FAILURE: RESULTS OF THE SHARF STUDY

June 6th, 2005

In a study reported at the ERA/EDTA Congress in Istanbul, Robert Lins and colleagues reported the results of a prospective study of treatment in acute renal failure, called the SHARF Project (Stuivenberg Hospital Acute Renal Failure).

Patients admitted to ICUs with serum Cr > 2.0 mg/dL were stratified into 3 classes of severity using a new SHARF scale developed at one of the participating centers, and then those deemed to require dialysis therapy were randomised to either daily 4-6 hr. hemodialysis or to CRRT.

RRT was required in 650 patients and randomisation was performed in 316 of them (49%). 144 patients were assigned to IHD, and 172 to CRRT. After correction for disease severity, there was no differenc in outcome between treatment modalities. Various exclusions or sugroup analyses failed to change the result.

JT Daugirdas