The ESA Controversy: The Role of Intravenous Iron

ASN Renal Week 2008 Official Symposium
Adeera Levin, MD

Molecular Control of Iron Transport
Tomas Ganz, MD, PhD

Continuous IV Iron Therapy in the Management of ESRD-Associated Anemia
Rajiv Agarwal, MD, MBBS, FASN

An Integrated Approach to Anemia Management in ESRD Patients
Anatole Besarab, MD, FACP

Audience questions and discussion
(Drs. Ganz, Agarwal, and Besarab)

Adeera Levin, MD, FRCPC (Moderator)
St. Paul's Hospital and University of British Columbia
Vancouver, BC, Canada

Tomas Ganz, MD, PhD
Professor of Medicine and Pathology,
Department of Medicine,
David Geffen School of Medicine at UCLA,
Los Angeles, CA, USA

Rajiv Agarwal, MD, MBBS, FASN
Associate Professor of Clinical Medicine at Indiana University and Richard L. Roudebush Veterans Administration Medical Center,
Indianapolis, Indiana

Anatole Besarab, MD, FACP
Director of Clinical Research,
Division of Nephrology and Hypertension,
Henry Ford Hospital,
Detroit, MI

This group of talks is accredited for up to 1.5 AMA PRA Category 1 credits™. This group of talks has a single post-test, which must be completed along with an evaluation form to obtain credit. The links to the post-test appear on the individual talk pages.
Date of Web Release: January 14, 2009
CME Credit Eligible Through: April 30, 2010
AMA PRA Category 1 Credits™: 1.5
Target Audiences: Physicians, researchers and trainees.
Method of participation: Listen to the talk, read the PubMed abstracts linked to data slides and talk references, take the post-test, read the abstracts linked to post-test answer feedback material.

Iron has become an important and commonly used therapy in the management of anemia associated with end-stage renal disease. Appropriate use of IV iron is perhaps even more critical now, given new limitations and guidelines associated with the use of ESAs. Benefits of iron include the correction of iron deficiency and potentiation of the therapeutic response to erythropoietic stimulating agents (ESA). However, concerns have been raised about potential adverse effects of iron. The purpose of this symposium is to address issues related to the use of iron in the management of anemic CKD patients. The molecular control of iron transport will first be reviewed focusing on the role of hepcidin and ferroportin on iron homeostasis. Issues regarding the use of iron in CKD patients will then be discussed. The final talk of this symposium will provide an integrated approach to anemia management that includes the systems that need to be in place for optimal management of anemia and therapeutic considerations in the use of IV iron and ESAs.


Accreditation Statement
The American Society of Nephrology is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CME Credit Designation Statement:
The American Society of Nephrology designates this educational activity for a maximum of 1.5 AMA PRA Category 1 Credits&trade. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This ASN Official Symposium was supported by an education grant from Watson Nephrology.

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Faculty disclosures are posted on each individual talk page.

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by FDA. The American Society of Nephrology and HDCN do not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. Faculty disclosure about unlabeled or off-label use is posted on each individual talk page.

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