HDCN Selected References on Hyperphosphatemia    

Consequences of Hyperphosphatemia: Are We Accepting the Unacceptable?

University of Minnesota
CME Internet Course

Selected References

Hyperphosphatemia, Acidosis, and PTH

Almaden Y, Canalejo A, Hernandez A, et al. Direct effect of phosphorus on parathyroid hormone secretion from whole rat parathyroid glands in vitro. J Bone Miner Res 1996; 11:970-976.

Alpern RJ, Sakhaee K. The clinical spectrum of chronic metabolic acidosis: Homeostatic mechanisms produced significant morbidity. (abstract) Am J Kidney Dis 1997; 29:291-302.

Amann K, Gross ML, London GM, Ritz E. Hyperphosphatemiaşa silent killer of patients with renal failure? Nephrol Dial Transplant 1999; 14:2085-2087.

Andress DL, Norris KC, Coburn JW, Slatopolsky EA, Sherrard DJ. Intravenous calcitriol in the treatment of refractory osteitis fibrosa of chronic renal failure. N Engl J Med 1989; 321:274-279.

Barzel US. The skeleton as an ion exchange system: Implications for the role of acid-base imbalance in the genesis of osteoporosis. J Bone Min Res 1995; 10:1431-1436.

Bettice JA. Skeletal carbon dioxide stores during metabolic acidosis. Am J Physiol 1984; 247:F326-F330.

Block GA, Hulbert-Shearon TE, Levin NW, Port FK. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study. Am J Kidney Dis 1998; 31:607-617.

Braun J, Oldendorf M, Moshage W, Heidler R, Zeitler E, Luft FC. Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients. Am J Kidney Dis 1996; 27:394-401.

Bro S, Olgaard K. Effects of excess PTH on nonclassical target organs. Am J Kidney Dis 1997; 30:606-620.

Bushinsky DA. Acid-base imbalance and the skeleton. In Burckhardt P, Dawson-Hughes B, Heaney RP. (eds.) Nutritional Aspects of Osteoporosis. Norwell, Massachusetts: Serono Symposia USA; 1998; 208.

Bushinsky DA. Acidosis and bone. Miner Electrolyte Metab 1994; 20:40-52.

Bushinsky DA. Bone disease in moderate renal failure: Cause, nature and prevention. Annu Rev Med 1997; 48:167-176.

Bushinsky DA. Metabolic alkalosis decreases bone calcium efflux by suppressing osteoclasts and stimulating osteoblasts. Am J Physiol 1996; 271:F216-F222.

Bushinsky DA. Renal osteodystrophy. In Jamison R, Wilkinson B, (eds.) Nephrology London: Chapman and Hall; 1997; 369.

Bushinsky DA. Stimulated osteoclastic and suppressed osteoblastic activity in metabolic but not respiratory acidosis. Am J Physiol 1995; 268:C80-C88. Bushinsky DA. The contribution of acidosis to renal osteodystrophy. Kidney Int 1995; 47:1816-1832.

Bushinsky DA, Chabala JM, Gavrilov KL, Levi-Setti R. Effects of in vivo metabolic acidosis on midcortical bone ion composition. (abstract) Am J Physiol: Renal Physiol 1999; 277.

Bushinsky DA, Gavrilov K, Chabala JM, Featherstone JDB, Levi-Setti R. Effect of metabolic acidosis on the potassium content of bone. J Bone Miner Res 1997; 12:1664-1671.

Bushinsky DA, Gavrilov K, Stathopoulos VM, Krieger NS, Chabala JM, Levi-Setti R. Effects of osteoclastic resorption on bone surface ion composition. Am J Physiol 1996; 271:C1025-C1031.

Bushinsky DA, Nilsson EL. Additive effects of acidosis and parathyroid hormone on mouse osteoblastic and osteoclastic function. Am J Physiol 1995; 269:C1364-C1370.

Chertow GM, Burke SK, Dillon MA, Slatopolsky E. Long-term effects of sevelamer hydrochloride on the calcium x phosphate product and lipid profile of hemodialysis patients. (in press) Nephrol Dial Transplant 1999.

Chertow GM, Martin KJ. Current and future therapies for the medical management of secondary hyperparathyroidism. Semin Dial 1998; 11:267-270.

Dabbagh S, Chesney R, Gusowski N, et al. Amino aciduria of vitamin D deficiency is independent of PTH levels and urinary cyclic AMP. Miner Electrolyte Metab 1989; 15:221-232.

Denda M, Finch J, Slatopolsky E. Parathyroid hyperplasia and secondary hyperparathyroidism develop rapidly in experimental uremic rats. J Bone Miner Res 1995; 10:S276.

Frick KK, Bushinsky DA. Chronic metabolic acidosis reversibly inhibits extracellular matrix gene expression in mouse osteoblasts. Am J Physiol 1998; 275:F840-F847.

Frick KK, Bushinsky DA. In vitro metabolic and respiratory acidosis selectively inhibit osteoblastic matrix gene expression. (abstract) Am J Physiol: Renal Physiol 1999; 277.

Frick KK, Jiang L, Bushinsky DA. Acute metabolic acidosis inhibits the induction of osteoblastic egr-1 and type 1 collagen. Am J Physiol 1997; 272:C1450-C1456.

Gonzalez EA, Martin KJ. Renal osteodystrophy: Pathogenesis and management. Nephrol Dial Transplant 1995; 3:13-21.

Green J, Kleeman CR. Role of bone in regulation of systemic acid-base balance. Kidney Int 1991; 39:9-26.

Jowsey J, Reiss E, Canterbury JM. Long-term effect of high phosphate intake on parathyroid hormone levels and bone metabolism. Acta Orthop Scand 1974; 45:801-806.

Kilav R, Silver J, Naveh-Many T. Parathyroid hormone gene expression in hypophosphatemia rats. J Clin Invest 1995; 96:327-333.

LaFlame GH, Jowsey J. Bone and soft tissue changes with oral phosphate supplements. J Clin Invest 1972; 51:2834-2839.

Lefebvre A, De Vernejoul MC, Gueris J, Goldfarb B, Graulet AM, Morieux C. Optimal correction of acidosis changes progression of dialysis osteodystrophy. Kidney Int 1989; 36:1112-1118.

Levin NW, Hulbert-Shearon TE, Strawderman RL, Port FK. (abstract) J Am Soc Nephrol 1998.

Llach F, Massry SG, Koffler A. Secondary hyperparathyroidism in early renal failure: Role of phosphate retention. Kidney Int 1977; 12:459-463.

Lopez-Hilker S, Dusso A, Rapp N, et al. Phosphorus restriction reverses secondary hyperparathyroidism in chronic renal failure independent of changes in calcium and 1,25 dihydroxycholecalciferol. Am J Physiol 1990; 259:F432-F437.

Lowrie EG, Lew NL. Death risk in hemodialysis patients: The predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis 1990; 15:458-482.

Lucas PA, Brown RC, Woodhead JS, et al. 1,25 Dihydroxycholecalciferol and parathyroid hormone in advanced chronic renal failure: Effects of simultaneous protein and phosphorus restriction. Clin Nephrol 1986; 25:7-10.

Manchais SJ, Metivier F, Guerin AP, London GM. Association of hyperphosphatemia with haemodynamic disturbances in end- stage renal disease. Nephrol Dial Transplant 1999; 14:2178-2183.

Massry SG, Goldstein DA. Role of parathyroid hormone in uremic toxicity. Kidney Int 1978; Suppl 8:S39-S42.

Naveh-Many T, Rahamimov R, Livni N. et al. Parathyroid cell proliferation in normal and chronic renal failure rats: The effects of calcium, phosphate and vitamin D. J Clin Invest 1995; 96:1786-1793.

Nielsen PK, Feldt-Rasmusen U, Olgaard K. A direct effect of phosphate on PTH release from bovine parathyroid tissue slices but not from dispersed parathyroid cells. Nehprol Dial Transplant 1996; 11:1762-1768.

Piraino B, Chen T, Cooperstein L, Segre G, Puschett J. Fractures and vertebral bone mineral density in patients with renal osteodystrophy. Clin Nephrol 1988; 30:57-62.

Raiz LG, Niemann I. Effect of phosphate calcium and magnesium on bone resorption and hormonal response in tissue culture. Endocrinology 1969; 85:446-452.

Rao DS, Shih MS, Mohini R. Effect of serum parathyroid hormone and bone marrow fibrosis on the response to erythropoetin in uremia. N Engl J Med 1993; 328:171-175. Rostand SG, Dreke TB. Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure. Kidney Int 1999; 56:383-392.

Schaefer K, Erley CM, vonHerrath D, et al. Calcium salts of ketoacids as a new treatment strategy for uremic hyperphosphatemia. Kidney Int 1989; 36:S136-S139.

Sebastian A, Harris ST, Ottaway JH, Todd KM, Morris RC, Jr. Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 1994; 330:1776-1781.

Silver J, Naveh-Many T, Mayer H, et al. Regulation by vitamin D metabolites of parathyroid gene transcription in vivo in the rat. J Clin Invest 1986; 78:1296-1301.

Slatopolsky E, Bricker N. The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease. Kidney Int 1973; 4:141-145.

Slatopolsky E, Finch J, Denda M, et al. Phosphate restriction prevents parathyroid cell growth in uremic rats. High phosphate directly stimulates PTH secretion in vitro. J Clin Invest 1996; 97:2534-2540.

Slatopolsky E, Finch J, Denda M, Ritter C, Zhong M, Dusso A, MacDonald PN, Brown AJ. Phosphorus restriction prevents parathyroid gland growth: High phosphorus directly stimulates PTH secretion in vitro. J Clin Invest 1996; 97:2534-2540.

Takahashi F, Finch J, Brown AJ, et al. The effects of a low phosphorus diet on the secretion of PTH in establishing diffuse parathyroid hyperplasia. (abstract) J Am Soc Nephrol 1997; 8:580.

Tessitore N, Venturi A, Adami S, et al. Relationship between plasma vitamin D metabolites and dietary intake of phosphate in patients with early renal failure. Miner Electrolyte Metab 1987; 13:38-44.

Wang Q, Palnitkar S, Parfitt AM. Parathyroid cell proliferation in the rat: Effect of age and of phosphate administration and recovery. Endocrinology 1996; 137:4558-4562.

Yi H, Fukagawa M, Yamato H, et al. Prevention of enhanced parathyroid hormone secretion, synthesis and hyperplasia by mild dietary phosphorus restriction in early chronic renal failure in rats: possible direct role of phosphorus. Nephron 1995; 70:242-248.

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