Kailasam MT, Parmer RJ, Cervenka JH, WU A, Ziegler MG, Kennedy BP, Adegbile IA, O'Connor DT
Divergent effects of dihydropyridines and phenylalkalamine calcium channel antagonist classes on autonomic function in human hypertension

Hypertension (Jul) 26:143-149 1995

This study compared the acute and chronic effects of two different classes of calcium antagonists, i.e. felodipine (dihydropyridine class) and verapamil (phenylalkylamine class), on sympathetic outflow measures in 15 patients with essential hypertension. Patients taking dihydropyridine drugs demonstrated decreases in blood pressure associated with increased sympathetic activity as assessed by reflex tachycardia and elevation of plasma norepinephrine activity. Conversely, patients receiving verapamil evidenced suppressed sympathetic activity.

Perhaps this may be one explanation why therapy of hypertension with dihydropyridine calcium antagonists does not reduce mortality in spite of good apparent blood pressure control (see NHLBI news alert). (Bakris)

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H: Drug therapy : Calcium channel blockers