Weir MR, Gray JM, Paster R, Saunders E, for the Tandolapril
Multicenter Study Group
Differing mechanisms of action of angiotensin-converting enzyme
inhibition in black and white hypertensive patients
Hypertension
(Jul) 26:124-130 1995
Previous studies have suggested that black patients repond less well to ACE
inhibitors than do white pts, but the clinical significance has not been
clear. In this study, 207 white pts and 91 black pts were given
trandolapril
1-4 mg/d. A dose of 1 mg/d was as effective in whites as was 4 mg/d in
blacks despite the fact that the drug inhibited ACE equally in both racial
groups. The mechanism may relate to different sensitivity of the RAS (there
was a dose-related decrease in aldo seen only in blacks) or to non-RAS
factors.
(Bakris)
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H: Drug therapy :
ACE inhibitors
H: Special problems :
Ethnic populations