Prakash R, Miller CC III, Suki WN
Anticardiolipin antibody in patients on maintenance hemodialysis and its association with recurrent arteriovenous graft thrombosis

Am J Kidney Dis (Aug) 26:347-352 1995

In a 30 month retrospective analysis of 91 patients on chronic hemodialysis for at least six months, 22% of those with arteriovenous grafts (AVG) and 6% with arteriovenous fistulas (AVF) had IgG anticardiolipin antibodies. For those with AVG the odds ratio of having had 2 or more thromboses was 3.7 (95% C.I. 1.2 to 11.8; p< 0.04). Anticardiolipin antibody was not associated with thromboses in those with AVF.

A prospective study is now required to determine whether the presence of anticardiolipin antibody is causally related to thromboses. It will also be important to ascertain whether AVG actually elicit the development of anticardiolipin antibodies or whether antibodies were seen in patients with AVG because of selection bias. (Paller)

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Basic hemodialysis : Vascular Access: graft/fistula