Kaysen GA, Rathove V, Shearer GC, Depner TA
Mechanisms of hypoalbuminemia in hemodialysis patients
Kidney Int
(Aug) 48:510-516 1995
It is frequently assumed that hypoalbuminemia in HD patients
results from malnutrition. Albumin synthesis was found to be
significantly decreased in patients with Palb < 3.5 as compared
to patients with Palb > 4.0 (n=6 ea). There were no differences
in dietary intake, anthropometrics, PCR, or Kt/V. Palb and
synthesis rate correlated with plasma IGF-1. It is hypothesized
that decreased Palb and synthesis were determined by
non-nutritional factors, possibly IGF-1 mediated. The authors
suggest that hypoalbuminemia is not necessarily indicative of
malnutrition.
(Leehey)
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