Hebert LA, Dillon JJ, Middendorf DF, Lewis EF, Peter JB
Relationship between appearance of urinary red blood cell/white blood
cell casts and the onset of renal relapse in systemic
lupus erythematosus
Am J Kidney Dis
(Sep) 26:432-438 1995
This study involved 17 pts with DPGN followed under the Lupus Nephritis
Collaborative Study Group protocol at Ohio State University. Urinalyses
were
performed at at least 2 mo intervals. In pts with proteinuria > 1 g/24h,
appearance of cellular casts predicted renal relapse (increase in
proteinuria
or serum creatinine) in 24/25 instances (predictive value was much less in
pts w/o proteinuria). The relative value of various parameters of SLE
activity for predicting renal relapse were compared. Overall percent of pts
with renal relapse with the following parameters were: cellular casts 81;
increasing hematuria 43; increasing pyuria 14; decreasing serum C3 65.
Whether these findings can be used to make therapeutic decisions is unknown.
(Leehey)
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Proteinuria/Hematuria :
Lupus nephritis
Assessing renal function :
Urinary crystals, casts