Touchette MA, Patel RV, Anandan JV, Dumler F, Zarowitz BJ
Vancomycin removal by high-flux polysulfone hemodialysis
membranes in critically ill patients with end-stage renal disease
Am J Kidney Dis
(Sep) 26:469-474 1995
Clearance of vancomycin by high-flux dialyzers (e.g., F-80 or F-60) is
substantial (approx. 100 ml/min); thus, post HD supplements are necessary in
order to assure maintenance of therapeutic vanco levels (> 12 mg/l). The
authors suggest the following protocol: Give 1.0 g loading dose. Measure
vanco level 6h after the end of the first HD session following the loading
dose. If level < 12, give additional 1.0 g; if level 12-25, give 500 mg, if
level > 25, do not give supplement and obtain repeat vanco level 6h after
subsequent HD. Once a 6h post-HD concentration of 12-25 mg/l is obtained,
proceed with a 500 mg supplement after each HD.
(Leehey)
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