Welch M, Newstead CG, Smyth V, Dodd PD, Walker MG
Evaluation of dopexamine hydrochloride as a renoprotective
agent during aortic surgery
Ann Vasc Surg
(Sep) 9:488-492 1995
ATN is common after aortic surgery. The effect of a new synthetic
intravenous catecholamine dopexamine was studied in a randomized controlled
study of 15 patients given 2 ug/kg/min of the drug vs. 17 patients. given
saline.
Renal failure (>30% increase in serum creatinine or >30% decrease in
creatinine clearance) occurred in 8 (47%) of saline-treated vs. 2 (13%) of
dopexamine-treated patients. No patient required dialysis. It is concluded
that
dopexamine protects vs. renal impairment in patients. undergoing aortic
surgery.
Comment: Criteria for determination of renal impairment are flawed
since a 30% increase in serum creatinine is not equivalent to a 30% decline
in clearance; moreover, the number of patients studied was small and the
clinical
relevance of the findings is not clear.
(Leehey)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
ARF etiology :
Post surgical