Kawagishi T, Nishizawa Y, Konishi T, Kawasaki K, Emoto M,
Shoji T, Tabata T, Inoue T, Morii H
High resolution B-mode ultrasonography in evaluation of
atherosclerosis in uremia
Kidney Int
(Sep) 48:820-826 1995
High resolution B mode ultrasonography (HRBU) is a new non-invasive tool used
to quantify the degree
of atheriosclerosis. In this study, femoral and carotid intima-media
thickness (IMT) were compared
in 199 dialysis patients and 81 healthy age-matched controls. The dialysis
patients had higher IMT
of both arteries, particularly when patients older than 45 were considered,
and some had very high
values. Globally, dialysis patients had higher BP, triglycerides, and lower
HDL cholesterol. In
addition to the usual risk factors (age, cigarette smoking), the serum
phosphorus appeared to be an
independent risk factor for carotid IMT, and serum mid-region PTH level for
femoral IMT.
Interestingly, blood pressure and lipids were not predictors for IMT for
either artery.
Comment: This is a nice study with no really new insights. I am not
a strong believer in
significant R values observed in multiple regression analysis procedures.
Furthermore, the sample
size is extremely small. However, PTH and phosphorus may be related to
atherosclerosis
conceptually, so the findings are provocative. The study is interesting
primarily because of the
application of this new methodology to the study of atherosclerosis in
dialysis patients.
(Daugirdas)
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