Kawagishi T, Nishizawa Y, Konishi T, Kawasaki K, Emoto M, Shoji T, Tabata T, Inoue T, Morii H
High resolution B-mode ultrasonography in evaluation of atherosclerosis in uremia

Kidney Int (Sep) 48:820-826 1995

High resolution B mode ultrasonography (HRBU) is a new non-invasive tool used to quantify the degree of atheriosclerosis. In this study, femoral and carotid intima-media thickness (IMT) were compared in 199 dialysis patients and 81 healthy age-matched controls. The dialysis patients had higher IMT of both arteries, particularly when patients older than 45 were considered, and some had very high values. Globally, dialysis patients had higher BP, triglycerides, and lower HDL cholesterol. In addition to the usual risk factors (age, cigarette smoking), the serum phosphorus appeared to be an independent risk factor for carotid IMT, and serum mid-region PTH level for femoral IMT. Interestingly, blood pressure and lipids were not predictors for IMT for either artery.

Comment: This is a nice study with no really new insights. I am not a strong believer in significant R values observed in multiple regression analysis procedures. Furthermore, the sample size is extremely small. However, PTH and phosphorus may be related to atherosclerosis conceptually, so the findings are provocative. The study is interesting primarily because of the application of this new methodology to the study of atherosclerosis in dialysis patients. (Daugirdas)

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CRF by organ system : Cardiovascular/Hypertension