Pereira BJG, Snodgrass B, King AJ, Barger G, Chopra S,
Perella C
Cytokine production during in vitro hemodialysis with new and
formaldehyde- or renalin-reprocessed cellulose dialyzers
J Am Soc Nephrol
(Oct) 6:1304-1308 1995
Reprocessing of dialyzers has been shown to attenuate complement activation
by cellulose membranes; however, there is concern that reprocessing may be
associated with increased cytokine production which could be lead to
increased morbidity and mortality. To test this hypothesis, the production
of interleukin (IL)-1a by peripheral blood mononuclear cells (PBMC) during in
vitro dialysis with new or reprocessed dialyzers was compared. Whole blood
from healthy volunteers was circulated for 3h in the blood compartment; the
dialysate compartment was sealed. Total IL synthesis by unstimulated and
endotoxin-stimulated PBMC was measured by RIA. IL production was increased
slightly but not significantly by new dialyzers, formaldehyde-reprocessed
dialyzers and renalin-reprocessed dialyzers; endotoxin-stimulated IL
production was significantly increased with new dialyzers and
formaldehyde-reprocessed dialyzers but not by renalin-reprocessed dialyzers.
These data do not support the hypothesis that reprocessing of dialyzers
increases IL production.
(Leehey)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
Basic hemodialysis :
Reuse, theory and practice