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Article Review/Hyperlink
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Krepp HH, Graves SW, Price DA, Lazarus M, Ensign A, Soszynski
A, Hollenberg NK
Reversal of sodium pump inhibitor induced vascular smooth
muscle contraction with digibind
Am J Hypert
(Jan) 9:39-46 1996

The search continues for "natural digoxin-like substances" in hypertension.
In this report, such a sodium pump inhibitor, which has not yet been fully
characterized, was extracted from "volume loaded" peritoneal dialysis
patients. The extract contracted rabbit aorta, but only after about 8-10
hours. The time course was similar to that occurring with ouabain, and both
oubain and extract-induced contractile responses were blocked by digibind
(IgG Fab antibody fragments directed against digoxin).
Comment: This study suggests that, in addition to volume overload and
increased sympathetic activity in dialysis patients, increased levels of a
Na/K pump inhibitor may also contribute to hypertension. The clinical and
therapeutic implications of such a hypothesis remain to be worked out.
(John T. Daugirdas MD, University of Illinois at Chicago)
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