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Article Review/Hyperlink
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Haubitz M, Ehlerding G, Beigel A, Heuer U, et al
Clinical experience with a new recombinant hepatitis-B vaccine
in previous non-responders with chronic renal insufficiency
Clin Nephrol
(Mar) 45:180-182 1996

Haubitz et al report the efficacy of a new recombinant hepatitis-B
vaccine in 31 patients with inadequate antibody response to previous
hepatitis-B vaccination. The new vaccine contains important pre-S1,
pre-S2, and S epitopes of the viral envelope including both adw and ayw
subtypes. Seventy one per cent of the patients had anti-HBs antibody
titers greater that 10 IU/mL one month after the fourth injection. The
antibody titers showed a wide range and titers fell below 50 IU/mL in 40
per cent of the responders after 12 months.
Comment: Patients with chronic renal insufficiency have a decreased
antibody response to vaccination against hepatitis-B. The development of
new recombinant vaccines may result in a better understanding of the
immune response to viral infection and to improved response rates among
patients with renal failure. The new vaccine described in this
report successfully immunized more than half of a group of non-responders
to previous vaccination. (George R. Aronoff, M.D., University of
Louisville)
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