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Article Review/Hyperlink
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DeSouza CA, Dengel DR, Rogers MA, Cox K, Macko RF
The fibrinolytic system is not impaired in older men with
hypertension
Hypertension
(May) 27:1053-1058 1996

Impairment of the fibrinolytic system could predispose
hypertensives to thrombotic complications. This study was designed to test
this hypothesis.
Plasma concentrations of plasminogen activator (PA) and plasminogen
activator inhibitor-1 (PAI-1) were measured in 12 hypertensive and 11
normotensive older men. Metabolic characteristics, esp. insulin and lipid
levels, were similar in the 2 groups. No significant differences in PA and
PAI-1 were noted.
Comment: These results do not support the hypothesis that the
fibrinolytic system is impaired in older hypertensives.
(David J. Leehey, M.D., Loyola University at Chicago)
For original abstract from the AHA,
click here
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