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Mochizuki T, Wu G, Hayashi T, Xenophontos SL, et al
PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein
Science (May) 272:1339-1342 1996
The recent discovery of the second ADPKD gene and its associated protein is a major contribution to unraveling the mysteries of the pathogenesis of ADPKD. This gene on chromosome 4 and its protein have some similarities and homologies with polycystin, the protein product of the PKD1 gene on chromosome 16. The differences between these protein products may give clues as to why PKD2 with the same phenotype as PKD1 is a more benign disease and hopefully to insights into cyst formation, growth and eventual medical therapies for people with these genotypes. William M. Bennett, M.D., University of Oregon
The abstract for this article is available from the AAAS: Click here.
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