Antonios TFT, Cappuccio FP, Markandu ND, Sagnella GA,
A diuretic is more effective than a beta-blocker in
hypertensive patients not controlled on amlodipine and
(Jun) 27:1325-1328 1996
Combination therapy with a calcium channel blocker and ACE-inhibitor is now
in vogue, with a number
of combination pills available on the market. In this study, patients who
fail this therapy were
given either a diuretic, bendrofluazide 5 mg, atenolol 100 mg, or placebo.
The diuretic worked
best, better than atenolol or placebo.
Comment: The results underscore the usefulness of diuretic therapy.
(John T. Daugirdas, M.D., University of Illinois at Chicago)
The full text of this abstract is available from the AHA at: