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Article Review/Hyperlink
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Couttenye MM, D'Haese PC, an Hoof VO, Lemoniatou E, Goodman
W, Verpooten GA, DeBroe ME
Low serum levels of alkaline phosphatase of bone origin: agood
marker of adynamic bone disease in haemodialysis patients
Nephrol Dial Transplant
(Jun) 11:1065-1072 1996

Adynamic bone disease is a growing problem in the dialysis population.
Measurements of intact PTH
may be used to identify patients with adynamic bone disease, but with limited
sensitivity. Recently
attention has turned to use of bone alkaline phosphatase as a marker for bone
turnover. In this
paper, Couttenye et al found that bone alkaline phosphatase levels had a
greater positive predictive
value (75%) for adynamic bone disease (found in 37% of patients based on
histologic criteria) than
did intact PTH (65%) or osteocalcin (55%). The value of bone alkaline
phosphatase is more
extensively discussed by Dr. Stuart Sprague in a recent review of a related
paper published in
March, 1996 JASN by Urena
et al. (John T. Daugirdas, M.D., University of Illinois at Chicago)
The original abstract text is available from the NDT by
(clicking here)
.
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