HDCN Article Review/Hyperlink

Couttenye MM, D'Haese PC, an Hoof VO, Lemoniatou E, Goodman W, Verpooten GA, DeBroe ME

Low serum levels of alkaline phosphatase of bone origin: agood marker of adynamic bone disease in haemodialysis patients

Nephrol Dial Transplant (Jun) 11:1065-1072 1996

Adynamic bone disease is a growing problem in the dialysis population. Measurements of intact PTH may be used to identify patients with adynamic bone disease, but with limited sensitivity. Recently attention has turned to use of bone alkaline phosphatase as a marker for bone turnover. In this paper, Couttenye et al found that bone alkaline phosphatase levels had a greater positive predictive value (75%) for adynamic bone disease (found in 37% of patients based on histologic criteria) than did intact PTH (65%) or osteocalcin (55%). The value of bone alkaline phosphatase is more extensively discussed by Dr. Stuart Sprague in a recent review of a related paper published in March, 1996 JASN by Urena et al. (John T. Daugirdas, M.D., University of Illinois at Chicago)

The original abstract text is available from the NDT by (clicking here) .